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Table 1 A summary of clinical trials in BNCT

From: Early clinical experience utilizing scintillator with optical fiber (SOF) detector in clinical boron neutron capture therapy: its issues and solutions

No.

Tumortype

Reactor (Mode)

Irrad. time [min.]

Probe type

Fluence [n/cm2]

Expected fluence [n/cm2]

Estimation error (%)

SOF detector

Gold wire

Gold

SOF

Pull-out

Final

Pull-out

Final

1

G

KUR(E)

120

BP

1.01 × 1011

7.72 × 1011

1.12 × 1011

9.58 × 1011

8.93 × 1011

7.26

−4.46

2

G

KUR(E)

60

BP

1.29 × 1011

5.02 × 1011

1.17 × 1011

4.90 × 1011

4.68 × 1011

4.62

−2.68

3

F

KUR(E)

80

LS

2.18 × 1011

1.17 × 1012

2.09 × 1011

1.20 × 1012

1.11 × 1012

7.76

0.55

4

P

KUR(E)

83

LS

1.39 × 1011

6.22 × 1011

1.14 × 1011

4.82 × 1011

6.30 × 1011

−23.46

−18.66

5

G

KUR(E)

90

LS

1.18 × 1011

6.92 × 1011

2.03 × 1011

1.09 × 1012

1.22 × 1012

−10.22

−2.18

6

G

KUR(E)

87

LS

1.24 × 1011

7.25 × 1011

1.36 × 1011

7.86 × 1011

1.63 × 1012

−0.35

0.47

7

G

KUR(E)

90

LS

1.41 × 1011

8.27 × 1011

3.01 × 1011

1.93 × 1012

1.80 × 1012

6.89

−2.27

8

G

KUR(T)

60

LP

1.55 × 1011

6.02 × 1011

3.17 × 1011

1.21 × 1012

1.27 × 1012

−4.26

−2.82

9

M

KUR(T)

90

LP

7.86 × 1011

4.60 × 1012

9.27 × 1010

5.89 × 1011

5.56 × 1011

5.83

−2.46

10a

G

JRR4(E)

69

LP

2.64 × 1011

1.03 × 1012

3.05 × 1012

1.25 × 1013

1.41 × 1013

−11.10

−4.86

11

G

JRR4(E)

34

LP

4.19 × 1011

8.62 × 1011

3.14 × 1012

7.03 × 1012

7.13 × 1012

−1.43

−0.67

12b

G

JRR4(E)

32

LP

1.31 × 1010

2.68 × 1010

3.05 × 1012

6.49 × 1012

6.52 × 1012

−0.38

−3.30

13c

M

JRR4(T)

75

LP

6.61 × 1011

3.00 × 1012

8.30 × 1011

4.59 × 1012

4.26 × 1012

7.83

−0.15

14

G

KUR(E)

90

LP

2.08 × 1011

1.17 × 1012

3.11 × 1011

1.91 × 1012

1.87 × 1012

2.02

−6.28

15d

P

JRR4(E)

25

LL

4.43 × 1011

1.06 × 1012

2.91 × 1012

4.77 × 1012

4.85 × 1012

−1.61

0.65

16d

G

JRR4(E)

29

LL

5.76 × 1011

1.54 × 1012

2.93 × 1012

5.51 × 1012

5.67 × 1012

−2.84

−1.82

  1. In Tumor Type column, G,P,M and F stand for Gliobrastoma, Parotid cancer, Melanoma and Fibro sarcoma, respectively
  2. In Reactor (Mode) column, (E) and (T) stand for epi-thermal neutron and thermal neutron irradiation respectively
  3. In the Probe Type column, BP, LS, LP and LL stand for paired boron-loaded, single lithium mixed, paired lithium mixed and loop-type lithium mixed, respectively
  4. aIrradiation performed during craniotomy, SOF detector placed on the edge of the collimator instead of patient skin
  5. bSOF detector placed under patient ear tube
  6. cGold wire placed on the patient skin (Except case 14 all cases in JRR, gold wire placed inside the port)
  7. dFirst 10 min used for calculating the expected fluence
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Radiation Oncology

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