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Table 4 Ordinal logistic regression analysis for maximal grade dermatitis radiation (CTCAE v.4.03)

From: Impact of hypofractionation and tangential beam IMRT on the acute skin reaction in adjuvant breast cancer radiotherapy

Factor

 

Univariate analysis

Multivariate analysis

p value

p value

Estimate

Lower 95 % CI

Upper 95 % CI

Country of origin

Middle East vs. Asia vs. Africa vs. Europe or U.S.A.

0.17

    

Age at diagnosis (years)

≤median vs. >median

0.61

    

Volume of the PTV (cm3)

≤median vs. >median

0.01

0.0002

1.52

0.72

2.32

BMI

<25 vs. 25.0–29.9 vs. 30.0–34.9 vs. 35.0–39.9 vs. ≥40.0

0.03

    

Menopausal status

Pre- vs. post-menopausal

0.56

    

T classification

Tis, T0,T1,T2 vs. T3,T4

0.51

    

N classification

N0 vs. N1, N2, N3

0.28

    

Grading

G1, G2 vs. G3

0.61

    

ER status

Negative vs. positive

0.98

    

PR status

Negative vs. positive

0.79

    

Her2/neu status

Negative vs. positive

0.38

    

Fractionation regimen

CF vs. HF

<0.0001

<0.00001

2.14

1.32

3.33

Planning Target Volume (PTV)

Breast vs. chest wall

0.02

    

Locoregional lymph nodes treated as part of plan

Yes vs. no

0.76

    

Radiation technique

3DCRT vs. TB-IMRT

0.42

    

Chemotherapy

Neoadjuvant vs. adjuvant vs. no chemotherapy

0.22

    

Hormonal therapy

Yes vs. no

0.60

    
  1. Abbreviations: 95 % CI = 95 % confidence interval