Transcriptomic analyses of the radiation response in head and neck squamous cell carcinoma subclones with different radiation sensitivity: time-course gene expression profiles and gene association networks

Table 4 Significantly enriched pathways of early and late responding genes after ionizing radiation

	Subclone SP	CAL-33 parental	Subclone RP
Early and late responding pathways	Apoptosis
	Cellular senescence
	Cell cycle
	Cellular responses to stress
	Signaling by Wnt
	Signaling by Rho GTPases
Early responding pathways	DNA double-strand break repair
	Signaling by TGF-beta receptor complex	Interferon signaling	Cellular response to hypoxia
	TRAF6 mediated NF-kB activation
Late responding pathways	Signaling by TGF-beta receptor complex
	TRAF6 mediated NF-kB activation
	Interferon signaling
	Toll-Like receptors cascades
	Signaling by interleukins
	Extracellular matrix organization
	MAPK family signaling cascades
	NOD1/2 signaling pathway
	PI3K/AKT signaling in cancer
	Signaling by VEGF
	Signaling by EGFR
	Signaling by FGFR
	Signaling by NOTCH
	Signaling by ERBB2
	Signaling by ERBB4
	GPCR ligand binding	Base excision repair	GPCR ligand binding

ISSN: 1748-717X