Table 1 Significantly enriched pathways of genes differentially expressed in subclones SP and RP compared to the parental CAL-33 cells
CAL-33 SP vs parental | Common signalling pathways | CAL-33 RP vs parental |
|---|---|---|
Transmembrane transport of small molecules | Signaling by VEGF | Nonhomologous end-joining (NHEJ) |
GPCR ligand binding | Extracellular matrix organization | Homologous DNA pairing and strand exchange |
Signaling by Rho GTPases | RNA polymerase III transcription initiation | CD28 dependent PI3K/Akt signaling |
Interferon signaling | NOTCH1 intracellular domain regulates transcription | |
Signaling by interleukins | ||
Senescence-associated secretory phenotype (SASP) | ||
NOD1/2 signaling pathway | ||
TNFR1-induced NFkB signaling pathway | ||
Toll-like receptors cascades | ||
Death receptor signaling | ||
MAPK1/MAPK3 signaling |