Fig. 1

Experimental conditions for irradiation by Ir-192 HDR-RALS. a Schematic diagram of the experimental conditions. A 35-mm glass-bottom dish containing cultured HeLa-Fucci cells was coated with a Parafilm sheet. The dish and catheter were fixed on the table in the same plane using adhesive tape. Irradiation was performed in a water bath. b Dose distribution under these experimental conditions. Left panel: Isodose curves. Radiation dose of 6 Gy was prescribed at hypothetical treatment point A, 20 mm away from the Ir-192 source (dotted line), according to a simulation by the treatment planning system. The dotted line represents the moving range (4 cm) of the Ir-192. Right panel: absorption dose as a function of distance from the Ir-192 source on the X-axis. Absorption dose was determined using a TLD sheet; irradiation was performed in such a manner as to obtain 6 Gy at the point A, according to the simulation