Table 2 Definitions of Grading Parameters for the FNCLCC System [21]
From: Soft tissue sarcoma of the extremities: pending questions on surgery and radiotherapy
Parameter | Criterion |
|---|---|
Tumour Differentiation | |
Score 1 | Sarcoma closely resembling normal adult mesenchymal tissue (e.g., well-differentiated liposarcoma) |
Score 2 | Sarcomas for which histologic typing is certain (e.g. myxoid liposarcoma) |
Score 3 | Embryonal and undifferentiated sarcomas; sarcomas of uncertain type |
Mitosis Count | |
Score 1 | 0-9/10 HPF |
Score 2 | 10-19/10 HPF |
Score 3 | ≥20/10 HPF |
Tumour Necrosis (Microscopic) | |
Score 0 | No necrosis |
Score 1 | ≤50 % tumour necrosis |
Score 2 | >50 % tumour necrosis |
Histologic Grade | |
Grade 1 | Total score 2,3 |
Grade 2 | Total score 4,5 |
Grade 3 | Total score 6,7,8 |