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Fig. 5 | Radiation Oncology

Fig. 5

From: Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo

Fig. 5

Detection of DNA damage and of apoptosis induced by X-ray irradiation, the PAA-TiOxNPs, and their combination in vivo. a Localization of the PAA-TiOxNPs (as visualized using H-E staining). Brown dots indicate accumulation of the PAA-TiOxNPs (yellow arrows). b Detection of DNA damage by staining of γ-H2AX and DAPI in MIAPaCa-2 cells. c The number of γ-H2AX foci with the combination treatment was significantly higher than that with the single treatment. Data are shown as the mean ± SD. *p < 0.05. d Induction of apoptosis and its evaluation by TUNEL assay. e The number of apoptotic cells with the combination treatment was significantly higher than that with the single treatment. Data are shown as the mean ± SD. *p < 0.05

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Radiation Oncology

ISSN: 1748-717X

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