Table 2 Risk factors associated with RILD after reirradiation
Variables | RILD (+) | RILD (−) | Univariate | Multivariate | ||
|---|---|---|---|---|---|---|
p value | p value | OR | 95 % CI | |||
Total number | 13 | 23 | ||||
Liver function before 2nd RT | ||||||
Total bilirubin ≧2.0 mg/dL | 4 | 0 | 0.016 | |||
Albumin ≦3.5 g/dL | 8 | 4 | 0.007 | |||
Presence of ascites | 3 | 1 | 0.086 | |||
INR ≧1.71 | 0 | 0 | ||||
CTP score ≧6 | 10 | 4 | <0.0001 | 0.001 | 15.833 | 2.947 ~ 85.075 |
Presence of PVTT | 8 | 5 | 0.017 | |||
AST/ALT ≧3x of upper normal limit | 5 | 1 | 0.088 | |||
Hepatitis | ||||||
Hepatitis B infection | 6 | 10 | 0.877 | |||
Hepatitis C infection | 2 | 6 | 0.458 | |||
RT parameters of 2nd RT | ||||||
Mean CTV (cm3) | 158.8 ± 157.9 | 204.2 ± 348.7 | 0.740 | |||
Mean PTV (cm3) | 257.9 ± 207.8 | 314.4 ± 480.7 | 0.260 | |||
Mean normal liver dose (EQD2, Gy8) | 12.0 ± 6.8 | 10.2 ± 4.8 | 0.726 | |||
Mean normal liver volume (cm3) | 1173.4 ± 622.2 | 992.5 ± 196.1 | 0.332 | |||
Interval between 2 courses (month) | 8.1 ± 8.1 | 12.6 ± 12.3 | 0.247 | |||
Mean cumulative normal liver dose (EQD2, Gy8) | 32.0 ± 15.0 | 30.6 ± 9.7 | 0.233 | |||
Mean cumulative prescribed dose (EQD2, Gy15) | 82.8 ± 15.9 | 90.6 ± 15.4 | 0.065 | |||
Abutting score for two PTV | 1.3 ± 0.9 | 1.1 ± 0.7 | 0.548 | |||