Clinical parameters for predicting radiation-induced liver disease after intrahepatic reirradiation for hepatocellular carcinoma

Table 1 Characteristics of all patients

	Patients with RILD	Patients without RILD
Variables	N = 13	N = 23
Gender
Male	11	19
Female	2	4
Median age at reirradiation	64	71
Median age at reirradiation	(range, 32 to 77)	(range, 33 to 89)
TNM stage (AJCC 7th edition)
T1N0M0	2	4
T2N0M0	1	7
T3N0M0	5	9
T4N1M0	1	0
T3N0M1	4	3
Previous local treatment
Surgery	1	2
TAE/TACE	7	12
RFA/Cryo	2	5
Category of previous hepatitis
Hepatitis B infection	6	10
Hepatitis C infection	2	6
non-HBV and non-HCV induced	5	7
CTP scores before the 2nd RT	6.3 ± 1.1	5.2 ± 0.5
Interval between 2 courses (months) abutting score for two PTV	8.1 ± 8.1	12.6 ± 12.2
0	4	5
1	2	9
2	7	9
1st RT parameters
Mean prescribed dose (EQD₂, Gy)	49.5 ± 8.2	52.5 ± 5.7
Mean CTV (cm3)	392.9 ± 407.0	345.2 ± 565.0
Mean PTV (cm3)	257.9 ± 207.8	314.4 ± 480.7
Mean normal liver dose (EQD₂, Gy)	20.8 ± 11.3	20.1 ± 8.2
Mean normal liver volume (cm3)	1255.5 ± 569.4	926.5 ± 242.4
2nd RT parameters
Mean prescribed dose (EQD₂, Gy)	32.9 ± 14.5	40.6 ± 12.8
Mean CTV (cm3)	139.1 ± 150.2	211.3 ± 343.1
Mean PTV (cm3)	257.9 ± 207.8	314.4 ± 480.7
Mean normal liver dose (EQD₂, Gy)	12.3 ± 6.6	10.2 ± 5.5
Mean normal liver volume (cm3)	1173.4 ± 622.2	992.5 ± 196.1
Mean cumulative prescribed dose (EQD₂, Gy)	80.9 ± 17.8	94.4 ± 13.9
Mean cumulative normal liver dose (EQD₂, Gy)	32.5 ± 15.1	30.5 ± 9.6

Abbreviation: RILD radiation-induced liver disease, TNM stage was evaluated before reirradiation; TAE transarterial embolization, TACE transarterial chemo-embolization, RFA radiofrequency ablation, Cryo cryotherapy, RT radiotherapy, CTV clinical tumor volume, PTV planning target volume, EQD2 biologically equivalent doses calculated in 2Gy
Note: abutting score: if reirradiation applied to a PTV separated from the previous PTV because the tumors were located at different segments, this situation was defined as out-field reirradiation (score = 0). For patients receiving reirradiation at the same or adjacent segment, the 2nd PTVs might be partially included in the previous PTV (score 1), or completely included (score 2)

ISSN: 1748-717X