Dose level | Patient | Tumor site | Toxicity of combined sunitinib and RT (CTCAE 4.0 grade) | Radiation site toxicity (CTCAE 4.0 grade) | Postoperative complications (CTCAE 4.0 grade) |
---|---|---|---|---|---|
1 | 1 | Lower extremity | neutropenia (3) thrombocytopenia (2) facial edema (1) fatigue (1) | 0 | prolonged wound drainage (1) |
1 | 2 | Lower extremity | - | 0 | wound dehiscence (3) |
1 | 3 | Retroperitoneal | lymphopenia (4) neutropenia (3) thrombocytopenia (3) gamma-glutamyl-transferase elevation (2) arterial hypertension (2) fatigue (1) | 1 | - |
1 | 4 | Retroperitoneal | lymphopenia (3) neutropenia (2) thrombocytopenia (1) genitourinary (2) diarrhea (2) | 0 | intraoperative bleeding (4) intraabd. abscess (3) myocardial ischemia (3) anastomotic leakage (3) |
1 | 5 | Retroperitoneal | lymphopenia (3) neutropenia (2) thrombocytopenia (1) arterial hypertension (2) dry mouth (1) diarrhea (1) | 1 | - |
1 | 6 | Groin | lymphocytopenia (3) neutropenia (1) diarrhea (2) dysgeusia (1) | 2 | - |
2 | 7 | Retroperitoneal | lymphopenia (2) neutropenia (2) thrombocytopenia (1) nausea (2) dry mouth (2) | 2 | - |
2 | 8 | Lower extremity | neutropenia (1) thrombocytopenia (1) vaginal mucositis (2) hand foot syndrome (1) nausea (1) oral mucositis (1) epistaxis (1) | 2 | prolonged wound drainage (2) lymphedema (2) |
2 | 9 | Chest wall | lymphopenia (3) neutropenia (1) thrombocytopenia (1) oral mucositis (1) fatigue (1) | 1 | delayed wound healing (1) |