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Table 2 Toxicity of study treatment and postoperative complications of the individual patients

From: Combined sunitinib and radiation therapy for preoperative treatment of soft tissue sarcoma: results of a phase I trial of the German interdisciplinary sarcoma group (GISG-03)

Dose level Patient Tumor site Toxicity of combined sunitinib and RT (CTCAE 4.0 grade) Radiation site toxicity (CTCAE 4.0 grade) Postoperative complications (CTCAE 4.0 grade)
1 1 Lower extremity neutropenia (3) thrombocytopenia (2) facial edema (1) fatigue (1) 0 prolonged wound drainage (1)
1 2 Lower extremity - 0 wound dehiscence (3)
1 3 Retroperitoneal lymphopenia (4) neutropenia (3) thrombocytopenia (3) gamma-glutamyl-transferase elevation (2) arterial hypertension (2) fatigue (1) 1 -
1 4 Retroperitoneal lymphopenia (3) neutropenia (2) thrombocytopenia (1) genitourinary (2) diarrhea (2) 0 intraoperative bleeding (4) intraabd. abscess (3) myocardial ischemia (3) anastomotic leakage (3)
1 5 Retroperitoneal lymphopenia (3) neutropenia (2) thrombocytopenia (1) arterial hypertension (2) dry mouth (1) diarrhea (1) 1 -
1 6 Groin lymphocytopenia (3) neutropenia (1) diarrhea (2) dysgeusia (1) 2 -
2 7 Retroperitoneal lymphopenia (2) neutropenia (2) thrombocytopenia (1) nausea (2) dry mouth (2) 2 -
2 8 Lower extremity neutropenia (1) thrombocytopenia (1) vaginal mucositis (2) hand foot syndrome (1) nausea (1) oral mucositis (1) epistaxis (1) 2 prolonged wound drainage (2) lymphedema (2)
2 9 Chest wall lymphopenia (3) neutropenia (1) thrombocytopenia (1) oral mucositis (1) fatigue (1) 1 delayed wound healing (1)