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Table 3 Some of larger published papers about hypo-fractionated stereotactic radiotherapy (HSRT) alone for large brain metastases

From: Hypo-fractionated stereotactic radiotherapy alone using volumetric modulated arc therapy for patients with single, large brain metastases unsuitable for surgical resection

Authors N. pts Total dose/n.frs mLC mos 1 yr b LC% mOS mos 1 yr b OS% Toxicity %
Aoyama [14] 87 35 Gy/4 NR 81 8.7 39 5
Ernst-Stecken [15] 51 35 Gy/5 7 76 % 11 NR 2
Fahrig [16] 150 30–35 Gy/5 NR NR 16 66 10
40 Gy/10 0
35 Gy/7
Narayana [17] 20 30 Gy/5 NR 70 8.5 64.5 2
Kim [19] 40 36 Gy/6 NR 69 8 34 5
Ogura [20] 39 35 Gy/5 NR 86.7   64.5 2
Minniti [23] 135 36 Gy/3 NR 88 14.8 57 7
27 Gy/3
Rajakesari [24] 70 25 Gy/5 17 56 10.7 NR 4.3
Croker [25]a 61 24 Gy/3 9 69 21 60 7
  1. Pts patients, frs fractions, mLC median local control, yr year, mOS median overall survival, mos months
  2. aIncluding patients underwent surgery plus hypofractionated stereotactic radiosurgery (HSRS)
  3. bActuarial