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Table 3 Some of larger published papers about hypo-fractionated stereotactic radiotherapy (HSRT) alone for large brain metastases

From: Hypo-fractionated stereotactic radiotherapy alone using volumetric modulated arc therapy for patients with single, large brain metastases unsuitable for surgical resection

Authors

N. pts

Total dose/n.frs

mLC mos

1 yr b LC%

mOS mos

1 yr b OS%

Toxicity %

Aoyama [14]

87

35 Gy/4

NR

81

8.7

39

5

Ernst-Stecken [15]

51

35 Gy/5

7

76 %

11

NR

2

Fahrig [16]

150

30–35 Gy/5

NR

NR

16

66

10

40 Gy/10

0

35 Gy/7

Narayana [17]

20

30 Gy/5

NR

70

8.5

64.5

2

Kim [19]

40

36 Gy/6

NR

69

8

34

5

Ogura [20]

39

35 Gy/5

NR

86.7

 

64.5

2

Minniti [23]

135

36 Gy/3

NR

88

14.8

57

7

27 Gy/3

Rajakesari [24]

70

25 Gy/5

17

56

10.7

NR

4.3

Croker [25]a

61

24 Gy/3

9

69

21

60

7

  1. Pts patients, frs fractions, mLC median local control, yr year, mOS median overall survival, mos months
  2. aIncluding patients underwent surgery plus hypofractionated stereotactic radiosurgery (HSRS)
  3. bActuarial