Hypo-fractionated stereotactic radiotherapy alone using volumetric modulated arc therapy for patients with single, large brain metastases unsuitable for surgical resection

Table 1 Patients, tumor and treatment characteristics

Patients	N. 102				%
Gender
Female	39				38
Male	63				62
Age (median)	61 years (range 30–93 years)
Histology
Breast Cancer	18				17
NSCLC	57				56
Melanoma	12				12
Other (CCC, Colon)	15				15
Stage at diagnosis of primary tumor
I–III	51				50
IV	51				50
KPS at BM diagnosis
100	18				17
90	18				17
80	63				63
70	3				3
RPA class
I	18				18
II	81				79
III	3				3
GPA score	0–1	1.5–2.5	3	3.5–4
Breast cancer	0	6	12	0
NSCLC	12	36	3	6
Melanoma	0	0	6	6
Other	0	12	3	0
Other extracranial metastatic site at diagnosis of BM	66				65
BM median maximum diameter cm (range cm)	2.9 (2.1–5)
BM diameter cm
2.1–3 cm	51				50
3.1–5 cm	51				50
GTV median volume cm³ (range cm³)	16.3 (3.9–64.5)
PTV median volume cm³ (range cm³)	33.7 (9.2–122.3)
HSRS Total dose/dose per fraction/n fractions
27 Gy/9 Gy/3	51				50
32 Gy/8 Gy/4	51				50

ISSN: 1748-717X