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Table 2 Chemotherapy and radiotherapy data for LRR/NP SCCHN patients undergoing reirradiation at Mayo Clinic

From: Outcomes of patients with loco-regionally recurrent or new primary squamous cell carcinomas of the head and neck treated with curative intent reirradiation at Mayo Clinic

  Surgery/PRRT DRRT P
RRT + concurrent chemotherapy 28 (67) 32 (82) 0.11
Type
 Cisplatin 17 (61) 7 (22) 0.002
 Cetuximab 8 (29) 11 (34)
 Cisplatin + cetuximab 0 3 (9)
 Carboplatin 1 (3) 5 (16)
 Other 2 (7) 6 (19)
Median primary radiotherapy dose 66 Gy (50–72 Gy) 66 Gy (26.4–79.2) 0.62
Median RRT dose 60 Gy (12–70 Gy) 69.6 Gy (48–76.8 Gy) <0.0001
RRT dose
  < 60 Gy 11 (26) 1 (3) -
  ≥ 60 to < 70 Gy 25 (60) 8 (20)
  ≥ 70 Gy 6 (14) 30 (77)
Primary radiotherapy technique
 IMRT 22 (52) 11 (28) 0.95
 3D conformal 13 (31) 18 (46)
 No information 7 (17) 10 (26)
RRT technique
 IMRT 36 (86) 38 (97) 0.08
 IMRT/IORT 3 (7) 0
 3D conformal 3 (7) 1 (3)x
  1. DRRT definitive reirradiation therapy, IMRT intensity modulated radiation therapy, IORT intra-operative radiation therapy, PRRT post-operative reirradiation therapy, RRT reirradiation