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Table 1 Demographics and disease-related information by treatment group among 81 LRR/NP SCCHN patients undergoing reirradiation at Mayo Clinic

From: Outcomes of patients with loco-regionally recurrent or new primary squamous cell carcinomas of the head and neck treated with curative intent reirradiation at Mayo Clinic

Characteristic

Surgery/PRRT n (%)

DRRT n (%)

P

# patients

42 (52)

39 (48)

 

Sex

 Male

34 (81)

27 (69)

0.22

 Female

8 (19)

12 (31)

 

Age, years

 Median (range)

61 (34–83)

65 (36–83)

0.23

Original primary site

 BOT/OP

10 (24)

14 (36)

0.23

 OC/FOM

7 (17)

3 (8)

 Larynx

15 (36)

17 (44)

 Sinus

2 (5)

0 (0)

 Other

4 (9)

4 (10)

 Unknown primary

4 (9)

1 (2)

Relapse at primary site

17 (41)

11 (28)

 

 BOT/OP

2 (12)

5 (46)

0.20

 OC/FOM

3 (18)

2 (18)

 Larynx/stoma

10 (58)

4 (36)

 Sinus

1 (6)

0 (0)

 Nasal cavity

1 (6)

0 (0)

Relapse at other site, not considered NP

14 (33)

17 (44)

 

 BOT/OP

0 (0)

1 (6)

0.06

 OC/FOM

1 (7)

0 (0)

 Sinus

1 (7)

0 (0)

 Nasopharynx

1 (7)

1 (6)

 Contra. Neck

7 (50)

2 (11)

 Ipsilat. Neck

4 (29)

10 (59)

 Supraclavicular

0 (0)

1 (6)

 Trachea

0 (0)

2 (11)

NP site

11 (26)

11 (28)

 

 BOT/OP

2 (18)

7 (64)

0.07

 OC/FOM

2 (18)

0 (0)

 Larynx

5 (45)

2 (18)

 Sinus

1 (9)

0 (0)

 Nasal cavity

1 (9)

0 (0)

 Nasopharynx

0 (0)

2 (18)

Mean LRR/NP size, cm (SD)

3.4 (1.48)

3.2 (0.98)

0.785

Median # positive lymph nodes (range)

1 (0–9)

N/A

 

LRR/NP Grade

 2

6 (16)

2 (9)

0.19

 3

20 (56)

18 (78)

 4

10 (28)

3 (13)

# ECE

19 (45)

N/A

 

# LVI

10 (24)

N/A

 

# perineural invasion

10 (24)

N/A

 

# positive margins

11 (26)

N/A

 

Tobacco use

 0

6 (14)

8 (21)

0.77

 <20 PY

6 (14)

5 (13)

 ≥20 OY

25 (60)

22 (56)

 UTQ

5 (12)

4 (10)

Alcohol abuse by history

14 (33)

10 (26)

0.41

  1. BOT base of tongue, DRRT definitive reirradiation therapy, ECE extracapsular extension, FOM floor of mouth, LVI lymphovascular invasion, LRR loco-regionally recurrent, NP new primary, OC oral cavity, OP oropharynx, PRRT post-operative reirradiation therapy, PY pack-year, SD standard deviation, UTQ unable to quantify