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Table 1 Demographics and disease-related information by treatment group among 81 LRR/NP SCCHN patients undergoing reirradiation at Mayo Clinic

From: Outcomes of patients with loco-regionally recurrent or new primary squamous cell carcinomas of the head and neck treated with curative intent reirradiation at Mayo Clinic

Characteristic Surgery/PRRT n (%) DRRT n (%) P
# patients 42 (52) 39 (48)  
Sex
 Male 34 (81) 27 (69) 0.22
 Female 8 (19) 12 (31)  
Age, years
 Median (range) 61 (34–83) 65 (36–83) 0.23
Original primary site
 BOT/OP 10 (24) 14 (36) 0.23
 OC/FOM 7 (17) 3 (8)
 Larynx 15 (36) 17 (44)
 Sinus 2 (5) 0 (0)
 Other 4 (9) 4 (10)
 Unknown primary 4 (9) 1 (2)
Relapse at primary site 17 (41) 11 (28)  
 BOT/OP 2 (12) 5 (46) 0.20
 OC/FOM 3 (18) 2 (18)
 Larynx/stoma 10 (58) 4 (36)
 Sinus 1 (6) 0 (0)
 Nasal cavity 1 (6) 0 (0)
Relapse at other site, not considered NP 14 (33) 17 (44)  
 BOT/OP 0 (0) 1 (6) 0.06
 OC/FOM 1 (7) 0 (0)
 Sinus 1 (7) 0 (0)
 Nasopharynx 1 (7) 1 (6)
 Contra. Neck 7 (50) 2 (11)
 Ipsilat. Neck 4 (29) 10 (59)
 Supraclavicular 0 (0) 1 (6)
 Trachea 0 (0) 2 (11)
NP site 11 (26) 11 (28)  
 BOT/OP 2 (18) 7 (64) 0.07
 OC/FOM 2 (18) 0 (0)
 Larynx 5 (45) 2 (18)
 Sinus 1 (9) 0 (0)
 Nasal cavity 1 (9) 0 (0)
 Nasopharynx 0 (0) 2 (18)
Mean LRR/NP size, cm (SD) 3.4 (1.48) 3.2 (0.98) 0.785
Median # positive lymph nodes (range) 1 (0–9) N/A  
LRR/NP Grade
 2 6 (16) 2 (9) 0.19
 3 20 (56) 18 (78)
 4 10 (28) 3 (13)
# ECE 19 (45) N/A  
# LVI 10 (24) N/A  
# perineural invasion 10 (24) N/A  
# positive margins 11 (26) N/A  
Tobacco use
 0 6 (14) 8 (21) 0.77
 <20 PY 6 (14) 5 (13)
 ≥20 OY 25 (60) 22 (56)
 UTQ 5 (12) 4 (10)
Alcohol abuse by history 14 (33) 10 (26) 0.41
  1. BOT base of tongue, DRRT definitive reirradiation therapy, ECE extracapsular extension, FOM floor of mouth, LVI lymphovascular invasion, LRR loco-regionally recurrent, NP new primary, OC oral cavity, OP oropharynx, PRRT post-operative reirradiation therapy, PY pack-year, SD standard deviation, UTQ unable to quantify