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Table 2 Dosimetric sensitivity of OAR clinical maximum dose, D2cm 3

From: Short-course PET based simultaneous integrated boost for locally advanced cervical cancer

 

Bladder [Gy]

Rectum [Gy]

Sigmoid [Gy]

Param/Plan

VMAT

IMPT

VMAT

IMPT

VMAT

IMPT

Standard

1.77 ± 0.00

1.75 ± 0.00

1.75 ± 0.00

1.75 ± 0.01

1.75 ± 0.01

1.74 ± 0.00

SIB

1.92 ± 0.04

1.80 ± 0.01

1.85 ± 0.02

1.82 ± 0.02

1.81 ± 0.02

1.78 ± 0.01

SIB 3 mm shift

2.11 ± 0.08

2.02 ± 0.06

2.04 ± 0.04

2.00 ± 0.05

1.93 ± 0.05

1.88 ± 0.05

SIB 5 mm shift

2.23 ± 0.10

2.20 ± 0.09

2.16 ± 0.06

2.15 ± 0.06

2.02 ± 0.08

1.97 ± 0.08

  1. Dosimetric sensitivity analysis estimating increase of D2cm 3 to OARs from shifts towards the high dose area potentially caused by tumour shrinkage
  2. Values are EQD2 per fraction (α/β = 3) and in mean ± standard deviation of the mean