Acute toxicity in comprehensive head and neck radiation for nasopharynx and paranasal sinus cancers: cohort comparison of 3D conformal proton therapy and intensity modulated radiation therapy

Table 4 Univariate analysis of patient and treatment factors and toxicity endpoints at each time point

	G-tube dependent		Median change EMD			EMD > baseline			Median % weight loss			>10 % weight loss
Variable	Comp	3 mo	Comp	1 mo	3 mo	Comp	1 mo	3 mo	Comp	1 mo	3 mo	Comp	1 mo	3 mo
Age	0.65	0.86	0.59	0.76	0.31	0.26	0.64	0.68	0.31	0.89	0.92	0.06	0.42	0.67
Gender	>0.99	0.73	0.80	0.37	0.19	0.75	>0.99	0.72	0.65	0.84	0.42	0.72	0.75	0.19
Tumor site (NPx vs nasal/paranasal)	0.003	0.15	0.08	0.33	0.96	0.10	0.52	>0.99	0.17	0.19	0.29	>0.99	0.11	0.05
Histology (SCC vs non-SCC)	0.20	0.17	0.037	0.17	0.44	0.05	0.11	0.71	0.16	0.16	0.27	>0.99	0.20	0.34
T stage (T4 vs other)	0.52	0.30	0.051	0.19	0.71	0.007	0.11	0.44	0.18	0.13	0.21	0.12	0.053	0.025
N stage (N0 vs other)	0.21	0.48	0.17	0.024	0.19	0.33	0.75	>0.99	0.14	0.43	0.64	0.45	0.20	0.33
KPS (≥90 % vs <90 %)	0.06	0.04	0.44	0.40	0.49	0.20	0.34	0.05	0.33	0.27	0.68	>0.99	0.52	0.34
Chemotherapy (concurrent vs other)	0.004	0.08	0.033	0.15	0.38	0.042	0.05	0.66	0.007	0.09	0.96	0.66	0.11	0.11
Smoking history (none vs other)	0.11	0.08	0.014	0.33	0.85	0.027	0.20	0.27	0.05	0.16	0.36	>0.99	0.34	0.05
Active smoking at time of RT	>0.99	0.66	0.20	0.34	0.78	0.44	0.43	0.35	0.13	0.78	0.83	0.35	0.70	0.69
Diabetes mellitus	0.60	0.18	0.25	0.81	>0.99	0.26	0.58	0.55	>0.99	0.63	0.63	0.55	0.57	0.55
Modality (proton vs IMRT neck)	<0.001	0.004	<0.001	0.12	0.49	<0.001	0.046	0.12	0.07	0.13	0.15	0.45	0.09	0.020

EMD equivalent morphine dose, Comp at completion, NPx nasopharynx, SCC squamous cell carcinoma, KPS Karnofsky Performance Status, RT radiation therapy, IMRT intensity modulated radiation therapy P values <0.05 are in bold.

ISSN: 1748-717X