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Table 4 Univariate analysis of patient and treatment factors and toxicity endpoints at each time point

From: Acute toxicity in comprehensive head and neck radiation for nasopharynx and paranasal sinus cancers: cohort comparison of 3D conformal proton therapy and intensity modulated radiation therapy

  G-tube dependent Median change EMD EMD > baseline Median % weight loss >10 % weight loss
Variable Comp 3 mo Comp 1 mo 3 mo Comp 1 mo 3 mo Comp 1 mo 3 mo Comp 1 mo 3 mo
Age 0.65 0.86 0.59 0.76 0.31 0.26 0.64 0.68 0.31 0.89 0.92 0.06 0.42 0.67
Gender >0.99 0.73 0.80 0.37 0.19 0.75 >0.99 0.72 0.65 0.84 0.42 0.72 0.75 0.19
Tumor site (NPx vs nasal/paranasal) 0.003 0.15 0.08 0.33 0.96 0.10 0.52 >0.99 0.17 0.19 0.29 >0.99 0.11 0.05
Histology (SCC vs non-SCC) 0.20 0.17 0.037 0.17 0.44 0.05 0.11 0.71 0.16 0.16 0.27 >0.99 0.20 0.34
T stage (T4 vs other) 0.52 0.30 0.051 0.19 0.71 0.007 0.11 0.44 0.18 0.13 0.21 0.12 0.053 0.025
N stage (N0 vs other) 0.21 0.48 0.17 0.024 0.19 0.33 0.75 >0.99 0.14 0.43 0.64 0.45 0.20 0.33
KPS (≥90 % vs <90 %) 0.06 0.04 0.44 0.40 0.49 0.20 0.34 0.05 0.33 0.27 0.68 >0.99 0.52 0.34
Chemotherapy (concurrent vs other) 0.004 0.08 0.033 0.15 0.38 0.042 0.05 0.66 0.007 0.09 0.96 0.66 0.11 0.11
Smoking history (none vs other) 0.11 0.08 0.014 0.33 0.85 0.027 0.20 0.27 0.05 0.16 0.36 >0.99 0.34 0.05
Active smoking at time of RT >0.99 0.66 0.20 0.34 0.78 0.44 0.43 0.35 0.13 0.78 0.83 0.35 0.70 0.69
Diabetes mellitus 0.60 0.18 0.25 0.81 >0.99 0.26 0.58 0.55 >0.99 0.63 0.63 0.55 0.57 0.55
Modality (proton vs IMRT neck) <0.001 0.004 <0.001 0.12 0.49 <0.001 0.046 0.12 0.07 0.13 0.15 0.45 0.09 0.020
  1. EMD equivalent morphine dose, Comp at completion, NPx nasopharynx, SCC squamous cell carcinoma, KPS Karnofsky Performance Status, RT radiation therapy, IMRT intensity modulated radiation therapy P values <0.05 are in bold.