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Table 3 Comparison of mean dose to organs at risk by radiation modality when IMRT or proton therapy was used for treatment of the cervical lymph nodes

From: Acute toxicity in comprehensive head and neck radiation for nasopharynx and paranasal sinus cancers: cohort comparison of 3D conformal proton therapy and intensity modulated radiation therapy

  Node negative   Node positive  
Organ at risk IMRT (n = 10) Proton (n = 10) P IMRT (n = 16) Proton (n = 4) P
Oral cavity 31.5 5.1 <0.001 44.6 8.5 <0.001
Larynx 40.4 16.8 <0.001 44.5 21.4 0.002
Esophagus 28.7 5.9 <0.001 36.0 12.1 <0.001
Better spared parotid 27.5 15.4 <0.001 33.8 17.4 0.001
Lesser spared parotid 29.5 (n = 9) 19.0 (n = 10) 0.006 35.5 (n = 6) 18.4 (n = 1) N/A
  1. IMRT intensity modulated radiation therapy, Radiation dose expressed in Gy for IMRT and Gy (RBE) for proton therapy