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Table 3 Comparison of mean dose to organs at risk by radiation modality when IMRT or proton therapy was used for treatment of the cervical lymph nodes

From: Acute toxicity in comprehensive head and neck radiation for nasopharynx and paranasal sinus cancers: cohort comparison of 3D conformal proton therapy and intensity modulated radiation therapy

 

Node negative

 

Node positive

 

Organ at risk

IMRT (n = 10)

Proton (n = 10)

P

IMRT (n = 16)

Proton (n = 4)

P

Oral cavity

31.5

5.1

<0.001

44.6

8.5

<0.001

Larynx

40.4

16.8

<0.001

44.5

21.4

0.002

Esophagus

28.7

5.9

<0.001

36.0

12.1

<0.001

Better spared parotid

27.5

15.4

<0.001

33.8

17.4

0.001

Lesser spared parotid

29.5 (n = 9)

19.0 (n = 10)

0.006

35.5 (n = 6)

18.4 (n = 1)

N/A

  1. IMRT intensity modulated radiation therapy, Radiation dose expressed in Gy for IMRT and Gy (RBE) for proton therapy