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Table 2 Comparison of mean dose and biologically effective dose (using either α/β = 10 Gy (BED10) or 3 Gy (BED3) for tumor volumes and α/β = 3 Gy for all OARs) between sequential boost (SEQ) and the simultaneous integrated boost (SIB) schemes for all structures of the ten studied patients (mean ± SD)

From: Comparison of breast sequential and simultaneous integrated boost using the biologically effective dose volume histogram (BEDVH)

 

SEQ

SIB10

SIB3

Dose (Gy)

BED10 (Gy10)

BED3 (Gy3)

Dose (Gy)

BED10 (Gy10)

Dose

BED3 (Gy3)

PTVboost Prescription

66.0

79.2

110.0

64.4

79.2

62.9

110.0

PTVbreast Prescription

50.0

60.0

83.3

50.4

60.0

51.5

83.3

PTVboost

65.7 ± 0.7

78.7 ± 1.0

109.2 ± 1.7

64.2 ± 0.1

78.9 ± 0.1

62.6 ± 0.1

109.4 ± 0.3

PTVbreast

53.4 ± 0.7

63.8 ± 0.8

88.0 ± 1.0

52.2 ± 0.4

61.9 ± 0.6

52.8 ± 0.5

86.2 ± 1.0

ILung

9.0 ± 1.8

12.2 ± 2.7

8.2 ± 1.7

11.0 ± 2.5

8.2 ± 1.6

10.9 ± 2.4

CBreast

1.2 ± 0.4

1.3 ± 0.4

1.1 ± 0.3

1.2 ± 0.3

1.1 ± 0.2

1.2 ± 0.3

CLung

1.0 ± 0.3

1.0 ± 0.4

0.9 ± 0.2

0.9 ± 0.3

0.9 ± 0.2

0.9 ± 0.2

Heart (Lt.)

3.4 ± 0.7

3.9 ± 1.1

3.0 ± 0.9

3.5 ± 1.2

3.2 ± 0.7

3.6 ± 1.0

Heart (Rt.)

2.3 ± 0.5

2.4 ± 0.6

1.9 ± 0.2

2.0 ± 0.2

2.0 ± 0.6

2.1 ± 0.6