Status quo and directions in deep head and neck hyperthermia

Radiation Oncology

Table 1 Results of randomized phase III trials on hyperthermia for cancers in the head and neck

Reference	Tumor	Combi	N	Endpoint(s)	-HT	+HT	Heating	Quality control
Valdagni et al. 1988 & 1994 [18, 19]	Neck Nodes	RT	44	CR	41 %	83 %	Radiative (280–300 MHz)	Invasive, > 4 each HT session (periphery:core = 4:1)
				5 years LC	24 %	69 %
				5 years OS	0 %	50 %
Datta et al. 1990 [21]	OC, OP (stage I–IV)	RT	65	CR	31 %	55 %	Capacitive, (27.12 kHz)	-
Huilgol et al. 2010 [22]	OC, OP, HP (stage II–IV)	RT	54	CR	42 %	79 %	Capacitive (8 MHz)	Invasive (infrequent)
Hua et al. 2011 [25]	NP (stage I–IV)	CRT	180	5 years LC	79 %	91 %	Conduction (resistive wire)	Nasal cavity internal skin temperature
				5 years PFS	63 %	73 %
				5 years OS	70 %	78 %
Zhao et al. 2014 [27]	NP (stage II–IV)	CRT	83	3-years OS (QoL)	54 %	73 %	Capacitive	Nasal cavity internal skin temperature

RT Radiotherapy, CRT Chemo-radiotherapy, N total number of included patients in the study, −HT results without HT, +HT results with HT, LC local control, CR complete response, PFS progression free survival, OC oral cavity, OP oropharynx, HP hypopharynx, NP nasopharynx. Results in bold are significant at the 5 %-level. Toxicity was comparable in all randomized trials, although Zhao et al. found an improved quality of life (QoL)

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