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Table 1 Results of randomized phase III trials on hyperthermia for cancers in the head and neck

From: Status quo and directions in deep head and neck hyperthermia

Reference Tumor Combi N Endpoint(s) -HT +HT Heating Quality control
Valdagni et al. 1988 & 1994 [18, 19] Neck Nodes RT 44 CR 41 % 83 % Radiative (280–300 MHz) Invasive, > 4 each HT session (periphery:core = 4:1)
5 years LC 24 % 69 %
5 years OS 0 % 50 %
Datta et al. 1990 [21] OC, OP (stage I–IV) RT 65 CR 31 % 55 % Capacitive, (27.12 kHz) -
Huilgol et al. 2010 [22] OC, OP, HP (stage II–IV) RT 54 CR 42 % 79 % Capacitive (8 MHz) Invasive (infrequent)
Hua et al. 2011 [25] NP (stage I–IV) CRT 180 5 years LC 79 % 91 % Conduction (resistive wire) Nasal cavity internal skin temperature
5 years PFS 63 % 73 %
5 years OS 70 % 78 %
Zhao et al. 2014 [27] NP (stage II–IV) CRT 83 3-years OS (QoL) 54 % 73 % Capacitive Nasal cavity internal skin temperature
  1. RT Radiotherapy, CRT Chemo-radiotherapy, N total number of included patients in the study, −HT results without HT, +HT results with HT, LC local control, CR complete response, PFS progression free survival, OC oral cavity, OP oropharynx, HP hypopharynx, NP nasopharynx. Results in bold are significant at the 5 %-level. Toxicity was comparable in all randomized trials, although Zhao et al. found an improved quality of life (QoL)