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Table 2 Cytogenetic fibroblast analysis in the prospective and the retrospective study group

From: Frequent induction of chromosomal aberrations in in vivo skin fibroblasts after allogeneic stem cell transplantation: hints to chromosomal instability after irradiation

Study group

Prospective

Retrospective

 

before SCT (0 mo)

3 months after SCT

p-value (0 vs 3 mo)

12 months after SCT

p-value (0 vs 12 mo)

 

pat., n

18

13

 

11

 

17

pat. with aberrant metaphases, n (%)

2 (11 %)

12 (92 %)

0.002 (McNemar)

11 (100 %)

0.002 (McNemar)

17 (100 %)

aberrant metaphases/30 metaphases (%)1

13 %; 27 %2

77 % (0-100 %)

0.002 (Wilcoxon)

63 % (33-97 %)

0.003 (Wilcoxon)

83 % (33-100 %)

mean no. of breakpoints/aberrant metaphase1

2.3; 22

3.5 (2.3-6.8)

NA

2.9 (1.6-5.8)

NA

3.8 (1.8-5.4)

  1. Legend to Table 2: pat. = patients. no. = number. 1 Results are given in median and range. 2 Because only two patients had cytogenetic aberrations before SCT, median and range could not be given and only numbers of these two patients are shown. NA = not applicable because of small number of statistical events