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Table 1 Patients characteristic

From: Adjuvant radiation therapy of regional lymph nodes in breast cancer - a meta-analysis of randomized trials- an update

  MA.20 [10] EORTC [12] French [13]
Recruitment years 2000 - 2007 1996 - 2004 1991 - 1997
Number of patients 1832 4004 1334
Median age 54 54 57
Node positive 90 % 56 % 75 %
Breast surgery 100 % breast conserving 76 % breast conserving 100 % mastectomy
CHX 91 % 55 % 61 %
ER/PR negative 32 % 40 % 7 %
Unknown ER/PR Status n.a. n.a. 40 %
Her-2neu n.a. n.a. n.a.
Main inclusion criteria N+ or high risk* N0 any location N+ or medial tumor N+ or medial/central tumor
Breast/chest wall Both arms: Both arms: Both arms: according to practice of the center
50 Gy/25 fx 50 Gy/25 fx
Medial supraclavicular nodes Experimental arm: 45Gy/25 fx Experimental arm: 50 Gy/25 fx All patients: dose and fractionation according to practice of the center
Internal mammary nodes Experimental arm: 45Gy/25 fx Experimental arm: 50 Gy/25 fx Experimental arm: 45 Gy/20 fx
  1. *= > = 5 cm tumor, > = 2 cm tumor, and <10 axillary nodes removed with ER-, G3, or lymph vascular invasion; n.a. = not available; fx = fractions; ER = estrogene receptor; PR = progesterone receptor