Toxicity | Grade 1 | Grade 2 | Grade 3 | Grade 4 | All grades | |||||
---|---|---|---|---|---|---|---|---|---|---|
No. of events | % | No. of events | % | No. of events | % | No. of events | % | No. of events | % | |
Hematologic | ||||||||||
Anemia | 10 | 47,6 | 6 | 28,6 | 0 | 0 | 0 | 0 | 16 | 76,2 |
Leukopenia | 2 | 9,5 | 5 | 23,8 | 8 | 38,1 | 2 | 9,5 | 17 | 80,9 |
Granulocytopenia | 5 | 23,8 | 8 | 38,1 | 4 | 19 | 1 | 4,8 | 18 | 85,7 |
Thrombocytopenia | 12 | 57,2 | 2 | 9,5 | 1 | 4,8 | 0 | 0 | 15 | 71,4 |
Constitutional | ||||||||||
Fatigue | 8 | 38,1 | 2 | 9,5 | 0 | 0 | 0 | 0 | 10 | 47,6 |
Anorexia | 1 | 4,8 | 1 | 4,8 | 0 | 0 | 0 | 0 | 2 | 9,5 |
Gastrointestinal | ||||||||||
Nausea | 7 | 33,3 | 3 | 14,3 | 0 | 0 | 0 | 0 | 10 | 47,6 |
Vomiting | 3 | 14,3 | 1 | 4,8 | 0 | 0 | 0 | 0 | 4 | 19 |
Diarrhea | 1 | 4,8 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4,8 |
Liver and biliary | ||||||||||
Elevated total bilirubin | 1 | 4,8 | 1 | 4,8 | 0 | 0 | 0 | 0 | 2 | 9,5 |
Elevated AST/ALT | 6 | 28,6 | 3 | 14,3 | 0 | 0 | 0 | 0 | 9 | 4,3 |
Elevated Alkaline phosphatase | 5 | 23,8 | 3 | 14,3 | 1 | 4,8 | 0 | 0 | 9 | 4,3 |
Elevated Gamma-GT | 6 | 28,8 | 5 | 23,8 | 4 | 19 | 1 | 4,8 | 16 | 76,2 |
Acneiform Rash | 3 | 14,3 | 3 | 14,3 | 0 | 0 | 0 | 0 | 6 | 28,8 |