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Table 3 Toxicity profile of chemoradiation with Cetuximab in all 21 patients

From: Prospective study of cetuximab and gemcitabine in combination with radiation therapy: feasibility and efficacy in locally advanced pancreatic head cancer

Toxicity

Grade 1

Grade 2

Grade 3

Grade 4

All grades

 

No. of events

%

No. of events

%

No. of events

%

No. of events

%

No. of events

%

Hematologic

          

 Anemia

10

47,6

6

28,6

0

0

0

0

16

76,2

 Leukopenia

2

9,5

5

23,8

8

38,1

2

9,5

17

80,9

 Granulocytopenia

5

23,8

8

38,1

4

19

1

4,8

18

85,7

 Thrombocytopenia

12

57,2

2

9,5

1

4,8

0

0

15

71,4

Constitutional

          

 Fatigue

8

38,1

2

9,5

0

0

0

0

10

47,6

 Anorexia

1

4,8

1

4,8

0

0

0

0

2

9,5

Gastrointestinal

          

 Nausea

7

33,3

3

14,3

0

0

0

0

10

47,6

 Vomiting

3

14,3

1

4,8

0

0

0

0

4

19

 Diarrhea

1

4,8

0

0

0

0

0

0

1

4,8

Liver and biliary

          

 Elevated total bilirubin

1

4,8

1

4,8

0

0

0

0

2

9,5

 Elevated AST/ALT

6

28,6

3

14,3

0

0

0

0

9

4,3

 Elevated Alkaline phosphatase

5

23,8

3

14,3

1

4,8

0

0

9

4,3

 Elevated Gamma-GT

6

28,8

5

23,8

4

19

1

4,8

16

76,2

Acneiform Rash

3

14,3

3

14,3

0

0

0

0

6

28,8