Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study

Table 4 Association between hippocampal dosimetry and the status of NCF change in Wisconsin Card Sorting Test

Dosimetry	Dosimetric cut-off points	NCF Preservation N (%)	No preservation	p value
Bilateral hippocampi as a composite structure
Maximum	≤12.6 Gy	9(75.0 %)	3(25.0 %)	0.098
Maximum	>12.6 Gy	5(41.7 %)	7(58.3 %)	0.098
D_10%	≤8.81 Gy	7(58.3 %)	5(41.7 %)	1
D_10%	>8.81 Gy	7(58.3 %)	5(41.7 %)	1
D_20%	≤8.26 Gy	7(58.3 %)	5(41.7 %)	1
D_20%	>8.26 Gy	7(58.3 %)	5(41.7 %)	1
D_30%	≤7.95 Gy	6(50.0 %)	6(50.0 %)	0.408
D_30%	>7.95 Gy	8(66.7 %)	4(33.3 %)	0.408
D_40%	≤7.68 Gy	6(50.0)%	6(50.0 %)	0.408
D_40%	>7.68 Gy	8(66.7 %)	4(33.3 %)	0.408
D_50%	≤7.45 Gy	7(58.3 %)	5(41.7 %)	1
D_50%	>7.45 Gy	7(58.3 %)	5(41.7 %)	1
D_80%	≤6.80 Gy	7(58.3 %)	5(41.7 %)	1
D_80%	>6.80 Gy	7(58.3 %)	5(41.7 %)	1
D_100%	≤5.83 Gy	7(58.3 %)	5(41.7 %)	1
D_100%	>5.83 Gy	7(58.3 %)	5(41.7 %)	1
Left hippocampus
Maximum	≤12.41 Gy	10(83.3 %)	2(16.7 %)	0.013*
Maximum	>12.41Gy	4(33.3 %)	8(66.7 %)	0.013*
D_10%	≤8.75Gy	7(58.3 %)	5(41.7 %)	1
D_10%	>8.75 Gy	7(58.3 %)	5(41.7 %)	1
D_20%	≤8.22 Gy	7(58.3 %)	5(41.7 %)	1
D_20%	>8.22 Gy	7(58.3 %)	5(41.7 %)	1
D_30%	≤7.94 Gy	7(58.3 %)	5(41.7 %)	1
D_30%	>7.94 Gy	7(58.3 %)	5(41.7 %)	1
D_40%	≤7.70 Gy	7(58.3 %)	5(41.7 %)	1
D_40%	>7.70 Gy	7(58.3 %)	5(41.7 %)	1
D_50%	≤7.48 Gy	7(58.3 %)	5(41.7 %)	1
D_50%	>7.48 Gy	7(58.3 %)	5(41.7 %)	1
D_80%	≤6.73 Gy	7(58.3 %)	5(41.7 %)	1
D_80%	>6.73 Gy	7(58.3 %)	5(41.7 %)	1
D_100%	≤5.73 Gy	7(58.3 %)	5(41.7 %)	1
	>5.73 Gy	7(58.3 %)	5(41.7 %)

The status of neurocognitive change shown here is tailored to patients’ performance on Wisconsin Card Sorting Test – Perseverative Errors 4 months after the HS-WBRT course in 24 patients
The N (%) is listed to represent the number of patients and its corresponding percentage
* indicates that statistical significance is noted

ISSN: 1748-717X