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Table 4 Association between hippocampal dosimetry and the status of NCF change in Wisconsin Card Sorting Test

From: Hippocampal dosimetry correlates with the change in neurocognitive function after hippocampal sparing during whole brain radiotherapy: a prospective study

Dosimetry Dosimetric cut-off points NCF Preservation N (%) No preservation p value
Bilateral hippocampi as a composite structure
Maximum ≤12.6 Gy 9(75.0 %) 3(25.0 %) 0.098
>12.6 Gy 5(41.7 %) 7(58.3 %)
 D10% ≤8.81 Gy 7(58.3 %) 5(41.7 %) 1
>8.81 Gy 7(58.3 %) 5(41.7 %)
 D20% ≤8.26 Gy 7(58.3 %) 5(41.7 %) 1
>8.26 Gy 7(58.3 %) 5(41.7 %)
 D30% ≤7.95 Gy 6(50.0 %) 6(50.0 %) 0.408
>7.95 Gy 8(66.7 %) 4(33.3 %)
 D40% ≤7.68 Gy 6(50.0)% 6(50.0 %) 0.408
>7.68 Gy 8(66.7 %) 4(33.3 %)
 D50% ≤7.45 Gy 7(58.3 %) 5(41.7 %) 1
>7.45 Gy 7(58.3 %) 5(41.7 %)
 D80% ≤6.80 Gy 7(58.3 %) 5(41.7 %) 1
>6.80 Gy 7(58.3 %) 5(41.7 %)
 D100% ≤5.83 Gy 7(58.3 %) 5(41.7 %) 1
>5.83 Gy 7(58.3 %) 5(41.7 %)
Left hippocampus
Maximum ≤12.41 Gy 10(83.3 %) 2(16.7 %) 0.013*
>12.41Gy 4(33.3 %) 8(66.7 %)
 D10% ≤8.75Gy 7(58.3 %) 5(41.7 %) 1
>8.75 Gy 7(58.3 %) 5(41.7 %)
 D20% ≤8.22 Gy 7(58.3 %) 5(41.7 %) 1
>8.22 Gy 7(58.3 %) 5(41.7 %)
 D30% ≤7.94 Gy 7(58.3 %) 5(41.7 %) 1
>7.94 Gy 7(58.3 %) 5(41.7 %)
 D40% ≤7.70 Gy 7(58.3 %) 5(41.7 %) 1
>7.70 Gy 7(58.3 %) 5(41.7 %)
 D50% ≤7.48 Gy 7(58.3 %) 5(41.7 %) 1
>7.48 Gy 7(58.3 %) 5(41.7 %)
 D80% ≤6.73 Gy 7(58.3 %) 5(41.7 %) 1
>6.73 Gy 7(58.3 %) 5(41.7 %)
 D100% ≤5.73 Gy 7(58.3 %) 5(41.7 %) 1
  >5.73 Gy 7(58.3 %) 5(41.7 %)  
  1. The status of neurocognitive change shown here is tailored to patients’ performance on Wisconsin Card Sorting Test – Perseverative Errors 4 months after the HS-WBRT course in 24 patients
  2. The N (%) is listed to represent the number of patients and its corresponding percentage
  3. * indicates that statistical significance is noted