Table 4 Diagnostic performance of volume measurements for assessing overall treatment failure using MRI before treatment, at first BCT and final BCT
Evaluation | AUC; Significance | Interclass coefficient (average) | Cut-off | |
|---|---|---|---|---|
Observer 1 | Observer 2 | |||
Absolute volume analysis (n:35) | ||||
(a) MRI before treatment | 0.56 (0.37–0.75); - | 0.57 (0.38–0.76); - | 0.98 (0.96–0.99) | 28,6 cm3 |
(b) MRI at the first BCT | 0.82 (0.69–0.96); p < 0.01 | 0.78 (0.63–0.93); p = 0.02 | 0.95 (0.91–0.98) | 7,7 cm3 |
(c) MRI at the final BCT | 0.81 (0.67–0.96); p < 0.01 | 0.79 (0.63–0.95); p = 0.03 | 0.94 (0.89–0.97) | 2,8 cm3 |
Volume regression analysis (n:35) | ||||
First BCT MRI/MRI before treatment | 0.87 (0.75–0.99); p < 0.01 | 0.78 (0.72–1.00); p = 0.11 | 0.94 (0.87–0.97) | 72 % |
Final BCT MRI/MRI before treatment | 0.84 (0.69–0.89); p = 0.02 | 0.79 (0.63–0.95); p = 0.10 | 0.97 (0.95–0.99) | 89 % |