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Table 2 Effect of hydration on parotid gland volume and position during chemoradiotherapy

From: Geometric changes of parotid glands caused by hydration during chemoradiotherapy

  PG volume change relative to day−3 (%)
CRT RT CRT – RT
  Mean Median Mean Median Mean Median p
day−3 86.3 87.7 86.7 87.1    
day1 – day−3 +2.1 +1.8 −5.1 −4.5 7.2 6.3 <0.001
day2 – day−3 +5.1 +5.4 −5.6 −3.8 10.8 9.2 <0.001
day3 – day−3 +1.4 −1.8 −5.6 −4.7 7.0 2.8 0.016
day4 – day−3 −5.4 −6.9 −7.7 −7.3 2.2 0.4 0.601
day5 – day−3 −4.8 −4.8 −6.8 −6.7 2.0 1.9 0.511
  Medio-lateral distance change between PGs relative to day−3 (cm)
CRT RT CRT – RT
  Mean Median Mean Median Mean Median p
day−3 −0.24 −0.25 −0.30 −0.31    
day1 – day−3 +0.06 +0.04 −0.09 −0.09 0.15 0.13 <0.001
day2 – day−3 +0.12 +0.09 −0.10 −0.08 0.22 0.17 <0.001
day3 – day−3 +0.03 +0.00 −0.09 −0.10 0.12 0.10 0.109
day4 – day−3 −0.08 −0.13 −0.14 −0.11 0.06 −0.02 0.718
day5 – day−3 −0.08 −0.08 −0.12 −0.12 0.03 0.04 0.554
  1. Volume and position were determined from CBCT scans and expressed relative to the planning CT. Baseline volume and position were taken three days prior to start of hydration in the second chemotherapy cycle (week 4). Hydration started around treatment day 21, this day was renamed day 0. Significance (Mann–Whitney U-test) was tested against a control group receiving radiotherapy only. No significant results were found for the distance change between parotid glands in dorso-ventral and cranio-caudal direction
  2. PG(s) parotid gland(s), CRT chemoradiotherapy group, RT radiotherapy alone group