TY - JOUR AU - Schulz-Ertner, D. AU - Tsujii, H. PY - 2007 DA - 2007// TI - Particle radiation therapy using proton and heavier ion beams JO - J Clin Oncol VL - 25 UR - https://doi.org/10.1200/JCO.2006.09.7816 DO - 10.1200/JCO.2006.09.7816 ID - Schulz-Ertner2007 ER - TY - JOUR AU - Durante, M. AU - Loeffler, J. S. PY - 2010 DA - 2010// TI - Charged particles in radiation oncology JO - Nat Rev Clin Oncol VL - 7 UR - https://doi.org/10.1038/nrclinonc.2009.183 DO - 10.1038/nrclinonc.2009.183 ID - Durante2010 ER - TY - JOUR AU - Tsujii, H. AU - Kamada, T. PY - 2012 DA - 2012// TI - A review of update clinical results of carbon ion radiotherapy JO - Jpn J Clin Oncol VL - 42 UR - https://doi.org/10.1093/jjco/hys104 DO - 10.1093/jjco/hys104 ID - Tsujii2012 ER - TY - JOUR AU - Ohno, T. PY - 2013 DA - 2013// TI - Particle radiotherapy with carbon ion beams JO - EPMA J VL - 4 UR - https://doi.org/10.1186/1878-5085-4-9 DO - 10.1186/1878-5085-4-9 ID - Ohno2013 ER - TY - JOUR AU - Ohnishi, T. AU - Mori, E. AU - Takahashi, A. PY - 2009 DA - 2009// TI - DNA double-strand breaks: Their production, recognition, and repair in eukaryotes JO - Mutat Res VL - 669 UR - https://doi.org/10.1016/j.mrfmmm.2009.06.010 DO - 10.1016/j.mrfmmm.2009.06.010 ID - Ohnishi2009 ER - TY - JOUR AU - Falk, M. AU - Lukasova, E. AU - Kozubek, S. PY - 2010 DA - 2010// TI - Higher-order chromatin structure in DSB induction, repair and misrepair JO - Mutat Res VL - 704 UR - https://doi.org/10.1016/j.mrrev.2010.01.013 DO - 10.1016/j.mrrev.2010.01.013 ID - Falk2010 ER - TY - JOUR AU - Chapman, J. R. AU - Taylor, M. R. AU - Boulton, S. J. PY - 2012 DA - 2012// TI - Playing the end game: DNA double-strand break repair pathway choice JO - Mol Cell VL - 47 UR - https://doi.org/10.1016/j.molcel.2012.07.029 DO - 10.1016/j.molcel.2012.07.029 ID - Chapman2012 ER - TY - JOUR AU - Wang, C. AU - Lees-Miller, S. P. PY - 2013 DA - 2013// TI - Detection and repair of ionizing radiation-induced DNA double strand breaks: New developments in nonhomologous end joining JO - Int J Radiat Oncol Biol Phys VL - 86 UR - https://doi.org/10.1016/j.ijrobp.2013.01.011 DO - 10.1016/j.ijrobp.2013.01.011 ID - Wang2013 ER - TY - JOUR AU - Jeggo, P. A. AU - Geuting, V. AU - Löbrich, M. PY - 2011 DA - 2011// TI - The role of homologous recombination in radiation-induced double-strand break repair JO - Radiother Oncol VL - 101 UR - https://doi.org/10.1016/j.radonc.2011.06.019 DO - 10.1016/j.radonc.2011.06.019 ID - Jeggo2011 ER - TY - JOUR AU - Terato, H. AU - Tanaka, R. AU - Nakaarai, Y. AU - Nohara, T. AU - Doi, Y. AU - Iwai, S. PY - 2008 DA - 2008// TI - Quantitative analysis of isolated and clustered DNA damage induced by gamma-rays, carbon ion beams, and iron ion beams JO - J Radiat Res VL - 49 UR - https://doi.org/10.1269/jrr.07089 DO - 10.1269/jrr.07089 ID - Terato2008 ER - TY - JOUR AU - Asaithamby, A. AU - Hu, B. AU - Chen, D. J. PY - 2011 DA - 2011// TI - Unrepaired clustered DNA lesions induce chromosome breakage in human cells JO - Proc Natl Acad Sci U S A VL - 108 UR - https://doi.org/10.1073/pnas.1016045108 DO - 10.1073/pnas.1016045108 ID - Asaithamby2011 ER - TY - JOUR AU - Okayasu, R. AU - Okada, M. AU - Okabe, A. AU - Noguchi, M. AU - Takakura, K. AU - Takahashi, S. PY - 2006 DA - 2006// TI - Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway JO - Radiat Res VL - 165 UR - https://doi.org/10.1667/RR3489.1 DO - 10.1667/RR3489.1 ID - Okayasu2006 ER - TY - JOUR AU - Takahashi, A. AU - Yamakawa, N. AU - Kirita, T. AU - Omori, K. AU - Ishioka, N. AU - Furusawa, Y. PY - 2008 DA - 2008// TI - DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus JO - J Radiat Res VL - 49 UR - https://doi.org/10.1269/jrr.08007 DO - 10.1269/jrr.08007 ID - Takahashi2008 ER - TY - BOOK AU - Hall, E. J. AU - Giaccia, A. J. PY - 2012 DA - 2012// TI - Radiobiology for the Radiologist PB - Wilkins CY - Philadelphia ID - Hall2012 ER - TY - CHAP AU - Wouters, B. G. AU - Begg, A. C. ED - Joiner, M. ED - Kogel, A. PY - 2009 DA - 2009// TI - Irradiation-induced damage and the DNA damage response BT - Basic Clinical Radiobiology PB - Hodder Arnold Publication CY - London UR - https://doi.org/10.1201/b13224-3 DO - 10.1201/b13224-3 ID - Wouters2009 ER - TY - JOUR AU - Beucher, A. AU - Birraux, J. AU - Tchouandong, L. AU - Barton, O. AU - Shibata, A. AU - Conrad, S. PY - 2009 DA - 2009// TI - ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2 JO - EMBO J VL - 28 UR - https://doi.org/10.1038/emboj.2009.276 DO - 10.1038/emboj.2009.276 ID - Beucher2009 ER - TY - JOUR AU - Shibata, A. AU - Conrad, S. AU - Birraux, J. AU - Geuting, V. AU - Barton, O. AU - Ismail, A. PY - 2011 DA - 2011// TI - Factors determining DNA double-strand break repair pathway choice in G2 phase JO - EMBO J VL - 30 UR - https://doi.org/10.1038/emboj.2011.27 DO - 10.1038/emboj.2011.27 ID - Shibata2011 ER - TY - JOUR AU - Collis, S. J. AU - DeWeese, T. L. AU - Jeggo, P. A. AU - Parker, A. R. PY - 2005 DA - 2005// TI - The life and death of DNA-PK JO - Oncogene VL - 24 UR - https://doi.org/10.1038/sj.onc.1208332 DO - 10.1038/sj.onc.1208332 ID - Collis2005 ER - TY - JOUR AU - Chan, D. W. AU - Chen, B. P. AU - Prithivirajsingh, S. AU - Kurimasa, A. AU - Story, M. D. AU - Qin, J. PY - 2002 DA - 2002// TI - Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks JO - Genes Dev VL - 16 UR - https://doi.org/10.1101/gad.1015202 DO - 10.1101/gad.1015202 ID - Chan2002 ER - TY - JOUR AU - Chen, B. P. AU - Chan, D. W. AU - Kobayashi, J. AU - Burma, S. AU - Asaithamby, A. AU - Morotomi-Yano, K. PY - 2005 DA - 2005// TI - Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M408827200 DO - 10.1074/jbc.M408827200 ID - Chen2005 ER - TY - JOUR AU - Chen, B. P. AU - Uematsu, N. AU - Kobayashi, J. AU - Lerenthal, Y. AU - Krempler, A. AU - Yajima, H. PY - 2007 DA - 2007// TI - Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break JO - J Biol Chem VL - 282 UR - https://doi.org/10.1074/jbc.M611605200 DO - 10.1074/jbc.M611605200 ID - Chen2007 ER - TY - JOUR AU - Zhao, Y. AU - Thomas, H. D. AU - Batey, M. A. AU - Cowell, I. G. AU - Richardson, C. J. AU - Griffin, R. J. PY - 2006 DA - 2006// TI - Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441 JO - Cancer Res VL - 66 UR - https://doi.org/10.1158/0008-5472.CAN-05-4275 DO - 10.1158/0008-5472.CAN-05-4275 ID - Zhao2006 ER - TY - JOUR AU - Ciszewski, W. M. AU - Tavecchio, M. AU - Dastych, J. AU - Curtin, N. J. PY - 2014 DA - 2014// TI - DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin JO - Breast Cancer Res Treat VL - 143 UR - https://doi.org/10.1007/s10549-013-2785-6 DO - 10.1007/s10549-013-2785-6 ID - Ciszewski2014 ER - TY - JOUR AU - Shaheen, F. S. AU - Znojek, P. AU - Fisher, A. AU - Webster, M. AU - Plummer, R. AU - Gaughan, L. PY - 2011 DA - 2011// TI - Targeting the DNA double strand break repair machinery in prostate cancer JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0020311 DO - 10.1371/journal.pone.0020311 ID - Shaheen2011 ER - TY - JOUR AU - Takahashi, A. AU - Kubo, M. AU - Ma, H. AU - Nakagawa, A. AU - Yoshida, Y. AU - Isono, M. PY - 2014 DA - 2014// TI - Nonhomologous end-joining repair plays a more important role than homologous recombination repair in defining radiosensitivity after exposure to high-LET radiation JO - Radiat Res VL - 182 UR - https://doi.org/10.1667/RR13782.1 DO - 10.1667/RR13782.1 ID - Takahashi2014 ER - TY - JOUR AU - Ohno, T. AU - Kanai, T. AU - Yamada, S. AU - Yusa, K. AU - Tashiro, M. AU - Shimada, H. PY - 2011 DA - 2011// TI - Carbon ion radiotherapy at the Gunma University Heavy Ion Medical Center: new facility set-up JO - Cancers VL - 3 UR - https://doi.org/10.3390/cancers3044046 DO - 10.3390/cancers3044046 ID - Ohno2011 ER - TY - JOUR AU - Bolderson, E. AU - Richard, D. J. AU - Zhou, B. B. AU - Khanna, K. K. PY - 2009 DA - 2009// TI - Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair JO - Clin Cancer Res VL - 15 UR - https://doi.org/10.1158/1078-0432.CCR-09-0096 DO - 10.1158/1078-0432.CCR-09-0096 ID - Bolderson2009 ER - TY - JOUR AU - Gerelchuluun, A. AU - Manabe, E. AU - Ishikawa, T. AU - Sun, L. AU - Itoh, K. AU - Sakae, T. PY - 2015 DA - 2015// TI - The major DNA repair pathway after both proton and carbon-ion radiation is NHEJ, but the HR pathway is more relevant in carbon ions JO - Radiat Res VL - 183 UR - https://doi.org/10.1667/RR13904.1 DO - 10.1667/RR13904.1 ID - Gerelchuluun2015 ER - TY - JOUR AU - Yu, L. AU - Tumati, V. AU - Tseng, S. F. AU - Hsu, F. M. AU - Kim, D. N. AU - Hong, D. PY - 2012 DA - 2012// TI - DAB2IP regulates autophagy in prostate cancer in response to combined treatment of radiation and a DNA-PKcs inhibitor JO - Neoplasia VL - 14 UR - https://doi.org/10.1593/neo.121310 DO - 10.1593/neo.121310 ID - Yu2012 ER - TY - JOUR AU - Veuger, S. J. AU - Curtin, N. J. AU - Richardson, C. J. AU - Smith, G. C. AU - Durkacz, B. W. PY - 2003 DA - 2003// TI - Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1 JO - Cancer Res VL - 63 ID - Veuger2003 ER - TY - JOUR AU - Azad, A. AU - Jackson, S. AU - Cullinane, C. AU - Natoli, A. AU - Neilsen, P. M. AU - Callen, D. F. PY - 2011 DA - 2011// TI - Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells JO - Mol Cancer Res VL - 9 UR - https://doi.org/10.1158/1541-7786.MCR-11-0312 DO - 10.1158/1541-7786.MCR-11-0312 ID - Azad2011 ER - TY - JOUR AU - Li, Y. H. AU - Wang, X. AU - Pan, Y. AU - Lee, D. H. AU - Chowdhury, D. AU - Kimmelman, A. C. PY - 2012 DA - 2012// TI - Inhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation response JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0039588 DO - 10.1371/journal.pone.0039588 ID - Li2012 ER - TY - JOUR AU - Ismail, I. H. AU - Martensson, S. AU - Moshinsky, D. AU - Rice, A. AU - Tang, C. AU - Howlett, A. PY - 2004 DA - 2004// TI - SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization JO - Oncogene VL - 23 UR - https://doi.org/10.1038/sj.onc.1207303 DO - 10.1038/sj.onc.1207303 ID - Ismail2004 ER - TY - JOUR AU - Fontana, A. O. AU - Augsburger, M. A. AU - Grosse, N. AU - Guckenberger, M. AU - Lomax, A. J. AU - Sartori, A. A. PY - 2015 DA - 2015// TI - Differential DNA repair pathway choice in cancer cells after proton- and photon-irradiation JO - Radiother Oncol VL - 116 UR - https://doi.org/10.1016/j.radonc.2015.08.014 DO - 10.1016/j.radonc.2015.08.014 ID - Fontana2015 ER - TY - JOUR AU - Wang, H. AU - Wang, X. AU - Zhang, P. AU - Wang, Y. PY - 2008 DA - 2008// TI - The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation JO - DNA Repair VL - 7 UR - https://doi.org/10.1016/j.dnarep.2008.01.010 DO - 10.1016/j.dnarep.2008.01.010 ID - Wang2008 ER - TY - JOUR AU - Wang, H. AU - Zhang, X. AU - Wang, P. AU - Yu, X. AU - Essers, J. AU - Chen, D. PY - 2010 DA - 2010// TI - Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation JO - Nucleic Acids Res VL - 38 UR - https://doi.org/10.1093/nar/gkq069 DO - 10.1093/nar/gkq069 ID - Wang2010 ER - TY - JOUR AU - Li, Y. AU - Qian, H. AU - Wang, Y. AU - Cucinotta, F. A. PY - 2012 DA - 2012// TI - A stochastic model of DNA fragments rejoining JO - PLoS One VL - 7 UR - https://doi.org/10.1371/journal.pone.0044293 DO - 10.1371/journal.pone.0044293 ID - Li2012 ER - TY - JOUR AU - Aoki-Nakano, M. AU - Furusawa, Y. PY - 2013 DA - 2013// TI - Misrepair of DNA double-strand breaks after exposure to heavy-ion beams causes a peak in the LET-RBE relationship with respect to cell killing in DT40 cells JO - J Radiat Res VL - 54 UR - https://doi.org/10.1093/jrr/rrt064 DO - 10.1093/jrr/rrt064 ID - Aoki-Nakano2013 ER - TY - JOUR AU - Jette, N. AU - Lees-Miller, S. P. PY - 2015 DA - 2015// TI - The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis JO - Prog Biophys Mol Biol VL - 117 ID - Jette2015 ER - TY - JOUR AU - Deng, W. AU - Tsao, S. W. AU - Guan, X. Y. AU - Lucas, J. N. AU - Si, H. X. AU - Leung, C. S. PY - 2004 DA - 2004// TI - Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines JO - Oncogene VL - 23 UR - https://doi.org/10.1038/sj.onc.1208119 DO - 10.1038/sj.onc.1208119 ID - Deng2004 ER - TY - JOUR AU - IJpma, A. S. AU - Greider, C. W. PY - 2003 DA - 2003// TI - Short telomeres induce a DNA damage response in saccharomyces cerevisiae JO - Mol Biol Cell VL - 14 UR - https://doi.org/10.1091/mbc.02-04-0057 DO - 10.1091/mbc.02-04-0057 ID - IJpma2003 ER - TY - JOUR AU - Zhou, X. AU - Zhang, X. AU - Xie, Y. AU - Tanaka, K. AU - Wang, B. AU - Zhang, H. PY - 2013 DA - 2013// TI - DNA-PKcs inhibition sensitizes cancer cells to carbon-ion irradiation via telomere capping disruption JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0072641 DO - 10.1371/journal.pone.0072641 ID - Zhou2013 ER - TY - JOUR AU - Gustafsson, A. S. AU - Abramenkovs, A. AU - Stenerlöw, B. PY - 2014 DA - 2014// TI - Suppression of DNA-dependent protein kinase sensitize cells to radiation without affecting DSB repair JO - Mutat Res VL - 769 UR - https://doi.org/10.1016/j.mrfmmm.2014.06.004 DO - 10.1016/j.mrfmmm.2014.06.004 ID - Gustafsson2014 ER - TY - JOUR AU - Malu, S. AU - Malshetty, V. AU - Francis, D. AU - Cortes, P. PY - 2012 DA - 2012// TI - Role of non-homologous end joining in V(D)J recombination JO - Immunol Res VL - 54 UR - https://doi.org/10.1007/s12026-012-8329-z DO - 10.1007/s12026-012-8329-z ID - Malu2012 ER - TY - JOUR AU - Jung, D. AU - Giallourakis, C. AU - Mostoslavsky, R. AU - Alt, F. W. PY - 2006 DA - 2006// TI - Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus JO - Annu Rev Immunol VL - 24 UR - https://doi.org/10.1146/annurev.immunol.23.021704.115830 DO - 10.1146/annurev.immunol.23.021704.115830 ID - Jung2006 ER - TY - JOUR AU - Rothkamm, K. AU - Kuhne, M. AU - Jeggo, P. A. AU - Lobrich, M. PY - 2001 DA - 2001// TI - Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks JO - Cancer Res VL - 61 ID - Rothkamm2001 ER - TY - JOUR AU - Rief, N. AU - Lobrich, M. PY - 2002 DA - 2002// TI - Efficient rejoining of radiation-induced DNA double-strand breaks in centromeric DNA of human cells JO - J Biol Chem VL - 277 UR - https://doi.org/10.1074/jbc.M200265200 DO - 10.1074/jbc.M200265200 ID - Rief2002 ER - TY - JOUR AU - Elliott, B. AU - Jasin, M. PY - 2002 DA - 2002// TI - Double-strand breaks and translocations in cancer JO - Cell Mol Lif Sci VL - 59 UR - https://doi.org/10.1007/s00018-002-8429-3 DO - 10.1007/s00018-002-8429-3 ID - Elliott2002 ER - TY - JOUR AU - Bao, S. AU - Wu, Q. AU - McLendon, R. E. AU - Hao, Y. AU - Shi, Q. AU - Hjelmeland, A. B. PY - 2006 DA - 2006// TI - Glioma stem cells promote radioresistance by preferential activation of the DNA damage response JO - Nature VL - 444 UR - https://doi.org/10.1038/nature05236 DO - 10.1038/nature05236 ID - Bao2006 ER - TY - JOUR AU - Hambardzumyan, D. AU - Squatrito, M. AU - Holland, E. C. PY - 2006 DA - 2006// TI - Radiation resistance and stem-like cells in brain tumors JO - Cancer Cell VL - 10 UR - https://doi.org/10.1016/j.ccr.2006.11.008 DO - 10.1016/j.ccr.2006.11.008 ID - Hambardzumyan2006 ER - TY - JOUR AU - Rich, J. N. PY - 2007 DA - 2007// TI - Cancer stem cells in radiation resistance JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-07-0895 DO - 10.1158/0008-5472.CAN-07-0895 ID - Rich2007 ER - TY - JOUR AU - Nishikawa, S. AU - Ishii, H. AU - Haraguchi, N. AU - Kano, Y. AU - Fukusumi, T. AU - Ohta, K. PY - 2012 DA - 2012// TI - Genotoxic therapy stimulates error-prone DNA repair in dormant hepatocellular cancer stem cells JO - Exp Ther Med VL - 3 ID - Nishikawa2012 ER -