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Table 4 Dosimetric parameters (Mean ± Std. Error of Mean) stratified to the toxicity grading

From: Toxicity profile and early clinical outcome for advanced head and neck cancer patients treated with simultaneous integrated boost and volumetric modulated arc therapy

MUCOSAL TOXICITY

 

G0

G1

G2

G3

Oral Cavity

V30Gy [%]*

73.3 ± 4.4

73.4 ± 2.8

83.2 ± 1.7

84.3 ± 6.9

 

V40Gy [%]*

53.6 ± 5.2

53.0 ± 3.5

62.3 ± 2.5

70.5 ± 7.8

 

V70Gy [%]*

6.9 ± 2.8

8.8 ± 1.6

14.9 ± 2.1

17.4 ± 6.6

 

Mean [Gy]

42.5 ± 2.7

43.9 ± 1.4

47.7 ± 1.1

49.6 ± 4.4

SALIVARY TOXICITY

 

G0

G1

G2

G3

Parotid Ipsilateral

Mean [Gy]

30.0 ± 1.2

27.0 ± 1.1

34.9 ± 7.5

 

Parotid Contralateral

Mean [Gy]

22.4 ± 0.7

22.9 ± 0.6

23.8 ± 0.3

 

Parotids

Mean [Gy]

25.9 ± 0.7

25.1 ± 0.7

29.4 ± 3.7

 

Submandibulary Right

Mean [Gy]

61.0 ± 1.3

60.8 ± 1.5

60.5 ± 3.4

 

Submandibulary Left

Mean [Gy]

60.9 ± 1.3

62.2 ± 1.2

60.8 ± 3.7

 

SWALLOWING TOXICITY

 

G0

G1

G2

G3

Inferior Constrictor

D1/3V [Gy]*

45.9 ± 2.1

55.3 ± 2.6

54.5 ± 2.3

58.8 ± 6.1

 

D1/2V [Gy]*

43.0 ± 2.1

53.6 ± 2.8

52.0 ± 2.4

56.9 ± 6.4

 

D2/3V [Gy]*

40.1 ± 2.1

51.4 ± 2.8

49.2 ± 2.5

55.5 ± 6.7

 

V30Gy [%]*

84.0 ± 3.9

98.9 ± 0.6

98.0 ± 1.1

100.0 ± 0.1

 

V40Gy [%]*

55.6 ± 5.4

84.4 ± 6.1

78.2 ± 5.3

84.4 ± 13.9

 

V50Gy [%]*

28.4 ± 5.0

54.8 ± 9.0

52.0 ± 8.1

62.3 ± 18.5

 

Mean [Gy]*

43.4 ± 2.0

53.5 ± 2.6

51.9 ± 2.3

57.5 ± 6.1

Middle Constrictor

Mean [Gy]

56.8 ± 1.8

59.9 ± 1.9

62.5 ± 1.5

63.1 ± 3.9

Superior Constrictor

Mean [Gy]

62.4 ± 1.5

62.7 ± 1.5

63.6 ± 1.6

60.6 ± 3.1

  1. *Significant with p < 0.05