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Table 5 Significantly associated clinical characteristics

From: Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases

Authors LF DF LMC OS
Iwai et al. [19] Dose < 18Gy N/A Infratentorial location N/A
Jagannathan et al. [27] Greater treated volume N/A N/A Systemic progression
Karlovits et al. [31] N/A N/A N/A >1 intracranial metastasis
Extracranial disease
Jensen et al. [15] Preop diameter > 3 cm Dose <35Gy N/A N/A
Rwigema et al. [20] Greater PTV N/A N/A Age
RPA score
Choi et al. [21] N/A Melanoma histology N/A KPS
Preop diameter
Ogiwara et al. [33] N/A N/A N/A Extracranial metastases
Prabhu et al. [22] Larger PTV volume N/A N/A N/A
Marginal dose <18 Gy
Brennan et al. [34] NSCLC histology Infratentorial location N/A N/A
Preop diameter > 3 cm
Dural/ pial involvement
Hartford et al. [35] Preop diameter ≥ 2 cm Preop diameter ≥ 2 cm N/A GPA ≤1
Ojerholm et al. [18] Preop diameter ≥ 3 cm N/A Breast histology New diagnosis or untreated primary
Infratentorial location
Ling et al. [25] N/A Uncontrolled systemic disease N/A Increasing no. metastases
Melanoma histology Uncontrolled systemic disease
Increasing no. brain metastases
Present study N/A Synchronous metastases N/A Male gender
  1. LF local failure, N/A not applicable, PTV planning treatment volume, Preop preoperative, LMC leptomeningeal carcinomatosis, CK Cyberknife, OS overall survival, RPA recursive partitioning analysis, KPS Karnofsky performance status, GPA graded prognostic assessment, no. number