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Table 3 Literature of single fraction SRS to the resection cavity

From: Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases

Authors & year No. cavities Treatment modality Median dose (Gy) Crude LF (%) DF (%) Salvage WBRT (%) LMC (%) MS (mos)
Iwai et al., 2008 [19] 21 GK 17 24 48 NR 24 20
Do et al., 2009 [26] 33 LINAC 15 12 63 47 NR 12
Jagannathan et al., 2009 [27] 47 GK 19 7 87 28 NR 11
Karlovits et al., 2009 [28] 52 LINAC 15 8 55 31 NR 15
Limbrick et al., 2009 [29] 16 GK 20 27 60 40 NR 20
Hwang et al., 2010 [30] 25 GK 15–20a 0 33 NR NR 15
Kalani et al., 2010 [31] 68 GK 15 21 NR NR NR 13.2
Jensen et al., 2011 [15] 112 GK 17 13 54 37 7.5 10.9
Rwigema et al., 2011 [20] 77 CK 18 26 47 26 NR 14.5
Kelly et al., 2012 [32] 18 LINAC 18 11 35 24 NR N/A
Ogiwara et al., 2012 [33] 56 GK 16 9 38 14 NR 21
Prabhu et al., 2012 [22]b 64 LINAC 18 17 NR NR NR 13
Robbins et al., 2012 [16] 85 LINAC 16 19 55 35 8.2 12
Broemme et al., 2013 [23]b 44 LINAC 17c, 24d 9 66 36 NR 15.9
Hartford et al., 2013 [35] 49 LINAC 10 16 63 45 NR NR
Luther et al., 2013 [17] 120 GK 16 14 40 NR NR NR
Brennan et al., 2014 [34] 40 LINAC 18 30 47 NR NR 14.7
Ojerholm et al., 2014 [18] 96 GK 16 18 54 33 14 22.3
  1. No. number, GK Gamma Knife, LINAC linear accelerator, CK Cyberknife, LF local failure, DF distant failure, MS median survival, LMC leptomeningeal carcinomatosis, mos months, NR not reported, N/A not applicable
  2. aReported range
  3. bMajority single fraction SRS
  4. cMedian single fraction dose
  5. dMedian multi fraction dose