Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases

Radiation Oncology

Table 3 Literature of single fraction SRS to the resection cavity

Authors & year	No. cavities	Treatment modality	Median dose (Gy)	Crude LF (%)	DF (%)	Salvage WBRT (%)	LMC (%)	MS (mos)
Iwai et al., 2008 [19]	21	GK	17	24	48	NR	24	20
Do et al., 2009 [26]	33	LINAC	15	12	63	47	NR	12
Jagannathan et al., 2009 [27]	47	GK	19	7	87	28	NR	11
Karlovits et al., 2009 [28]	52	LINAC	15	8	55	31	NR	15
Limbrick et al., 2009 [29]	16	GK	20	27	60	40	NR	20
Hwang et al., 2010 [30]	25	GK	15–20^a	0	33	NR	NR	15
Kalani et al., 2010 [31]	68	GK	15	21	NR	NR	NR	13.2
Jensen et al., 2011 [15]	112	GK	17	13	54	37	7.5	10.9
Rwigema et al., 2011 [20]	77	CK	18	26	47	26	NR	14.5
Kelly et al., 2012 [32]	18	LINAC	18	11	35	24	NR	N/A
Ogiwara et al., 2012 [33]	56	GK	16	9	38	14	NR	21
Prabhu et al., 2012 [22]^b	64	LINAC	18	17	NR	NR	NR	13
Robbins et al., 2012 [16]	85	LINAC	16	19	55	35	8.2	12
Broemme et al., 2013 [23]^b	44	LINAC	17^c, 24^d	9	66	36	NR	15.9
Hartford et al., 2013 [35]	49	LINAC	10	16	63	45	NR	NR
Luther et al., 2013 [17]	120	GK	16	14	40	NR	NR	NR
Brennan et al., 2014 [34]	40	LINAC	18	30	47	NR	NR	14.7
Ojerholm et al., 2014 [18]	96	GK	16	18	54	33	14	22.3

No. number, GK Gamma Knife, LINAC linear accelerator, CK Cyberknife, LF local failure, DF distant failure, MS median survival, LMC leptomeningeal carcinomatosis, mos months, NR not reported, N/A not applicable
^aReported range
^bMajority single fraction SRS
^cMedian single fraction dose
^dMedian multi fraction dose

ISSN: 1748-717X