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Table 1 Comparison of patients characteristics, treatment factors and outcome between skin invasion (+) and (−) patients

From: Predictive value of skin invasion in recurrent head and neck cancer patients treated by hypofractionated stereotactic re-irradiation using a cyberknife

Variables Strata Skin invasion (−)   Skin invasion (+)   p-value
n = 95   n = 9   
   No. or mean +/− SD, median (range) (%) No. or median (range)   
Age   64 (43–88)   61 (56–83)   0.65
Gender Female 26 (27 %) 1 (11 %) 0.5
Male 69 (73 %) 8 (89 %)  
Disease Nasopharyngeal cancer 41 (43 %) 0 (0 %) 0.12
Oropharyngeal cancer 19 (20 %) 2 (22 %)  
Hypopharyngeal cancer 9 (9 %) 2 (22 %)  
Oral cancer 10 (11 %) 2 (22 %)  
Nasal/pranasal 16 (17 %) 3 (33 %)  
Irradiated area Primary 73 (77 %) 5 (56 %) 0.31
Lymph node 22 (23 %) 4 (44 %)  
rT stage T0 12 (13 %) 2 (22 %) 0.25
T1 18 (19 %) 0 (0 %)  
T2 9 (9 %) 1 (11 %)  
T3 11 (12 %) 3 (33 %)  
T4 30 (32 %) 3 (33 %)  
NA 15 (16 %) 0 (0 %)  
rN stage N0 69 (73 %) 4 (44 %) 0.32
N1 18 (19 %) 3 (33 %)  
N2 5 (5 %) 1 (11 %)  
N3 1 (1 %) 0 (0 %)  
NA 2 (2 %) 1 (11 %)  
Ulceration (−) 74 (78 %) 5 (56 %) 0.27
(+) 21 (22 %) 4 (44 %)  
Surgical history (−) 55 (58 %) 3 (33 %) 0.28
(+) 40 (42 %) 6 (67 %)  
Planning target volume cm3 26.2 (0.9–339)   64.6 (5.2–241)   0.04
Interval months 16.0 (1–1180)   8.3 (5.1–44)   0.1
Dose EQD2 (a/b = 10) 41.9 (18.9–74.7)   34.6 (31.2–57.8)   0.12
Cumulative dose EQD2 (a/b = 10) 117.1 (62–192)   105. 4 (96.6–130)   0.09
Initial tumor response CR + PR 55 (59 %) 0 (0 %) 0
SD + PD 38 (41 %) 9 (100 %)  
Toxicity Grade 0–2 78 (82 %) 5 (56 %) 0.14
Grade 3- 17 (18 %) 4 (44 %)  
  1. CR complete reponse, PR partial response, NC no change, PD progressive disease
  2. Bold values indicate statistically significance