Table 1 Comparison of patients characteristics, treatment factors and outcome between skin invasion (+) and (−) patients
Variables | Strata | Skin invasion (−) | Skin invasion (+) | p-value | ||
|---|---|---|---|---|---|---|
n = 95 | n = 9 | |||||
No. or mean +/− SD, median (range) | (%) | No. or median (range) | ||||
Age | 64 (43–88) | 61 (56–83) | 0.65 | |||
Gender | Female | 26 | (27 %) | 1 | (11 %) | 0.5 |
Male | 69 | (73 %) | 8 | (89 %) | ||
Disease | Nasopharyngeal cancer | 41 | (43 %) | 0 | (0 %) | 0.12 |
Oropharyngeal cancer | 19 | (20 %) | 2 | (22 %) | ||
Hypopharyngeal cancer | 9 | (9 %) | 2 | (22 %) | ||
Oral cancer | 10 | (11 %) | 2 | (22 %) | ||
Nasal/pranasal | 16 | (17 %) | 3 | (33 %) | ||
Irradiated area | Primary | 73 | (77 %) | 5 | (56 %) | 0.31 |
Lymph node | 22 | (23 %) | 4 | (44 %) | ||
rT stage | T0 | 12 | (13 %) | 2 | (22 %) | 0.25 |
T1 | 18 | (19 %) | 0 | (0 %) | ||
T2 | 9 | (9 %) | 1 | (11 %) | ||
T3 | 11 | (12 %) | 3 | (33 %) | ||
T4 | 30 | (32 %) | 3 | (33 %) | ||
NA | 15 | (16 %) | 0 | (0 %) | ||
rN stage | N0 | 69 | (73 %) | 4 | (44 %) | 0.32 |
N1 | 18 | (19 %) | 3 | (33 %) | ||
N2 | 5 | (5 %) | 1 | (11 %) | ||
N3 | 1 | (1 %) | 0 | (0 %) | ||
NA | 2 | (2 %) | 1 | (11 %) | ||
Ulceration | (−) | 74 | (78 %) | 5 | (56 %) | 0.27 |
(+) | 21 | (22 %) | 4 | (44 %) | ||
Surgical history | (−) | 55 | (58 %) | 3 | (33 %) | 0.28 |
(+) | 40 | (42 %) | 6 | (67 %) | ||
Planning target volume | cm3 | 26.2 (0.9–339) | 64.6 (5.2–241) | 0.04 | ||
Interval | months | 16.0 (1–1180) | 8.3 (5.1–44) | 0.1 | ||
Dose | EQD2 (a/b = 10) | 41.9 (18.9–74.7) | 34.6 (31.2–57.8) | 0.12 | ||
Cumulative dose | EQD2 (a/b = 10) | 117.1 (62–192) | 105. 4 (96.6–130) | 0.09 | ||
Initial tumor response | CR + PR | 55 | (59 %) | 0 | (0 %) | 0 |
SD + PD | 38 | (41 %) | 9 | (100 %) | ||
Toxicity | Grade 0–2 | 78 | (82 %) | 5 | (56 %) | 0.14 |
Grade 3- | 17 | (18 %) | 4 | (44 %) |