Fig. 1

Proliferation assays of SNB19 and A549 after treatment AZD6244 and/or NVP-BEZ235. Effect of 24 h exposure to serial dilutions of AZD6244 (blue squares), AZD6244 with 50 nM NVP-BEZ235 (red triangels), NVP-BEZ235 (green circles) or NVPBEZ235 with 500 nM AZD6244 (black diamonds) on the ATP level in SNB19 or A549 cells, as measured by a standard luciferase assay. The diagram represents the means of two independent experiments, each performed in triplicates, normalized against DMSO-treated controls. Dose–response curves (illustrated in the corresponding color) were generated using the standard four parameter logistic models and error bars indicate SD values