Skip to main content
Fig. 3 | Radiation Oncology

Fig. 3

From: The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis

Fig. 3

Treatment with BV6 elevates irradiation-induced nuclear foci formation. SW480, HT-29 and HCT-15 colorectal carcinoma cell lines were treated either with DMSO as a control or with 1 or 4 μM BV6 4 h before irradiation. Immunofluorescence staining for γH2AX (a) or 53BP1 (b) was accomplished 0, 1, 6, 12 and 24 h after irradiation with 2 Gy and nuclear foci were counted subsequently (means ± SD; n = 3; * P <0.05; Student’s t-test)

Back to article page

Radiation Oncology

ISSN: 1748-717X

Contact us