Table 4 Five year local control rates from studies employing hypofractionated radiotherapy for T1N0 and T20 squamous cell carcinoma of the glottis
Author/year | No. of patients | Dose (5 days/week daily fractionation unless stated) | Fraction size | OTT | tBED | Follow up/years | 5 year LC T1a | 5 year LC T1b | 5 year LC T2 |
|---|---|---|---|---|---|---|---|---|---|
Current series | 132 (n = 68 T1) | 55Gy in 20 | 2.75 | 26 | 67.0 | 6 | 91.8 % | 81.6 % | 80.9 % |
Moon et al. 2014 [26] | 156 (n = 139 T1) | RCT: | 5.6 | 5 years Local PFS | |||||
Conventional arm (n = 82): | T1/2: | ||||||||
77.8 % conv | |||||||||
66 in 33 for T1 | 2Gy | 44 | 62.3 | 88.5 % hypo | |||||
70Gy in 35 for T2 | 47 | 64.7 | |||||||
Hypofractionated arm (n = 74): | T1 only: | ||||||||
80.3 % conv | |||||||||
63Gy in 28 (T1) 67.5Gy in 30 for T2 | 2.25Gy | 38 | 64.9 | 90.1 % hypo | |||||
40 | 68.8 | ||||||||
T1a only: 76.7 % conv | |||||||||
93 % hypo | |||||||||
Kim et al. 2012 [27] | 157 (n=125 T1 only) | 70Gy in 35 (n = 64 pts) | 2Gy | 47 | 64.7 | 7.1 | All T1 | ||
83 % | 63 % | ||||||||
67.5Gy in 30 (n = 93) | 2.25Gy | 40 | 68.8 | 3.8 | 95 % | 61 % | |||
Laskar et al. 2012 [28] | 652 (T1 only) | 50Gy in 15 | 3.3Gy | 19 | 68.9 | 5 | All T1: 90.6 % >3Gy per fraction 86.8Gy <3Gy per fraction (NS difference between fractionation schedules) | ||
55Gy in 16 | 3.43Gy | 22 | 73.9 | ||||||
60Gy in 24 | 2.5Gy | 32 | 67.3 | ||||||
62.5 in 25 | 2.5Gy | 33 | 69.6 | ||||||
Jamshed et al. 2011 [30] | 87 (n = 83 T1) | 55Gy in 20 | 2.75 | 26 | 67.0 | 2.6 | LRC 95 % | LRC 88 % | n/a |
Chera et al. 2009 [16] | 585 (n = 325) | 63Gy in 28 (T1) | 2.25Gy | 38 | 64.9 | 12 | 94 % | 93 % | T2a 80 % |
65.25Gy in 29 (T2) | 39 | 66.8 | T2b 70 % | ||||||
(39 % of series includes other schedules including hyperfractionation) | |||||||||
Cheah et al. 2009 [11] | 100 (T1 only) | 50Gy in 16 fractions | 3.125Gy | 22 | 65.6 | 7 | 90 % | 85 % | N/A |
Short et al. 2006 [29] | 145 (n = 102 T1) | 60–66Gy in 30–33 (n = 51) | 2 | 40–44 | 58.1–62.3 | 4.9 | All T1 LRC 75 % conv | LRC 80 % (conv) | |
52.5-55Gy in 20 (n = 94) | 2.625–2.75 | 26 | 63.2–67.0 | LRC 91 % hypo | LRC 81 % (hypo) | ||||
Yamazaki et al. 2006 [8] | 180 (T1 only) | RCT: 60–66Gy in 30–33 | Not stated | All T1 | |||||
(66Gy if >2/3 of cord) (n = 89) | 2Gy | 40–44 | 58.1–62.3 | LC 77 % conv | |||||
56.25Gy in 25 or 63Gy in 28 (>2/3cord) (n = 91) | 2.25Gy | 33–38 | 60.4–64.9 | LC 92 % hypo | |||||
Gowda 2003 [12] | 200 (T1 only) | 50–52.5Gy in 16 | 3.12–3.28Gy | 22 | 65.6–68.7 | 5.8 | 93.1 % | 89.1 % | |