Risk of radiation-induced pneumonitis after helical and static-port tomotherapy in lung cancer patients and experimental rats

Table 2 A comparison of patient characteristics and radiation pneumonitis in lung cancer patients treated with tomotherapy according to the delivery mode of radiation beams

		Mode of tomotherapy		P-value
		Static	Helical	P-value
Smoking History	Yes	12/12 (83.3 %)	26/51 (51.0 %)	0.04
	No	2/12 (16.7 %)	25/51 (49.0 %)
PTV (cc)	Median (range)	158.50 (57–799)	144.00 (16–789)	NS
Total lung V10 (%)	median (range)	32.00 (11–70)	44.00 (5–98)	NS
Total lung V20 (%)	median (range)	16.00 (5–51)	16.00 (4–53)	NS
CCRTx	Yes	7/12 (58.3 %)	14/51 (27.5 %)	0.04
	No	5/12 (41.7 %)	37/51 (72.5 %)
Radiation pneumonitis scoring system
RTOG	Acute	3/ 12 (25.0 %)	15/51 (29.4 %)	NS
	Late	1/ 12 (8.3 %)	27/42 (64.3 %)	0.001
CTCAE	Acute	3/ 12 (25.0 %)	20/51 (39.2 %)	NS
	Late	1/ 12 (8.3 %)	20/42 (47.6 %)	0.01

CCRTx concurrent chemoradiotherapy, RTOG Radiation Therapy Oncology Group, CTCAE the National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0, NS not significant