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Table 3 NTCP LKB parameters of pooled human GI toxicity studies. An α/β ratio of 3 or 4, median or mean study EQD, and duodenal volumes of 1–5 % were used for analysis. Parameters and corresponding 95 % confidence intervals as calculated by the profile likelihood method are shown

From: Late gastrointestinal tissue effects after hypofractionated radiation therapy of the pancreas

NTCP model assumptions

NTCP model parameters

α/β

Volume

n (95 % CI)

m (95 % CI)

TD50 (95 % CI)

3

1 %

0.50 (0.47–0.53)

0.49 (0.46–0.52)

41.0 (36.2–47.4)

3

2 %

0.38 (0.35–0.42)

0.49 (0.46–0.52)

91.0 (80.3–105.4)

3

3 %

0.42 (0.38–0.46)

0.49 (0.46–0.52)

95.0 (83.9–110.1)

3

4 %

0.50 (0.46–0.54)

0.49 (0.46–0.52)

81.9 (72.3–94.9)

3

5 %

0.63 (0.58–0.67)

0.49 (0.46–0.52)

63.0 (55.6–72.9)

4

1 %

0.48 (0.45–0.51)

0.48 (0.45–0.51)

39.0 (34.7–44.7)

4

2 %

0.59 (0.56–0.62)

0.48 (0.45–0.51)

35.0 (31.1–40.1)

4

3 %

0.45 (0.42–0.50)

0.48 (0.45–0.51)

71.0 (63.1–81.5)

4

4 %

0.45 (0.42–0.50)

0.48 (0.45–0.51)

81.0 (71.9–92.9)

4

5 %

0.43 (0.40–.48)

0.48 (0.45–0.51)

95.0 (84.4–109.1)