Involved-field radiotherapy (IFRT) versus elective nodal irradiation (ENI) in combination with concurrent chemotherapy for 239 esophageal cancers: a single institutional retrospective study

Table 1 Patient and tumor characteristics

	ENI		IFRT
Factor	N	%	N	%	P value
Total	120		119
Sex
Female	13	11 %	21	18 %	0.13
Male	107	89 %	98	82 %
Age (y.o.)
Range	46–83		44–86		0.11
Median	67		68
Location
Ce	4	3 %	6	5 %	0.63
Ut	19	16 %	20	17 %
Mt	56	47 %	61	51 %
Lt	41	34 %	32	27 %
K-PS
-80 %	41	34 %	30	25 %	0.13
90–100 %	79	66 %	89	75 %
Cycle number of CTx
1	28	23 %	15	13 %	0.062
2	49	41 %	44	37 %
3	13	11 %	15	13 %
4	30	25 %	45	38 %
1–2	77	64 %	59	50 %	0.023
3–4	43	36 %	60	50 %
FDG-PET scan
Conducted No. SUV-max in primary tumor	61	51 %	103	87 %	<0.0001
0–5.0	17	28 %	25	21 %	0.59
5.0–10.0	14	23 %	19	16 %
10.0-	30	49 %	59	50 %
Clinical T classification
T1	27	23 %	13	11 %	0.0004
T2	19	16 %	14	12 %
T3	51	43 %	40	34 %
T4	23	19 %	52	44 %
Clinical N classification
N0	46	39 %	39	33 %	0.37
N1	74	62 %	80	67 %
Clinical M classification
M0	80	67 %	97	82 %	0.0040
M1	40	34 %	20	17 %
Clinical stage
I	21	18 %	21	18 %	0.24
II	28	24 %	19	16 %
III	32	27 %	45	38 %
IV	39	33 %	34	29 %
Histopathological type
Squamous cell carcinoma	113	95 %	109	92 %	0.44
Others	7	6 %	10	8 %
CTx regimen
CDDP/5-FU	40	34 %		%
NDP/5-FU	80	67 %		%
NDP/TS-1	0	0 %		%
Irradiated total dose
50Gy/50.4Gy	108	91 %	118	99 %	0.85
Under 50 Gy	3	3 %	1	1 %
Over 50.4 Gy	9	8 %	0	0 %

Abbreviation: ENI Elective nodal irradiation, IFRT Involved-field radiotherapy, Ce Cervical esophagus, Ut Upper thoracic esophagus, Mt Middle thoracic esophagus, Lt Lower thoracic esophagus, K-PS Karnofsky performance status, CTx Chemotherapy, FDG-PET Fluorodeoxyglucose positron emissioin tomography, SUV Standardized uptake value, N Number, No. Number

ISSN: 1748-717X