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Table 3 Multivariate analyses of overall survival

From: Impact of waiting time after surgery and overall time of postoperative radiochemotherapy on treatment outcome in glioblastoma multiforme

OS

All patients

Fractionation 33 × 1.8 Gy

Fractionation 30 × 2.0 Gy

Factor

HR (95 % CI)

p-value

HR (95 % CI)

p-value

HR (95 % CI)

p-value

Interval surgery → RCT

0.998 (0.987-1.009)

0.705

0.985 (0.970-1.001)

0.059

1.007 (0.994-1.020)

0.312

Age

1.033 (1.020-1.045)

<0.001

1.031 (1.015-1.047)

<0.001

1.040 (1.019-1.061)

<0.001

ECOG state > 1

0.984 (0.728-1.364)

0.984

0.956 (0.638-1.431)

0.522

0.974 (0.580-1.636)

0.920

RPA-class > 4

1.210 (0.905-1.617)

0.199

1.240 (0.862-1.784)

0.247

1.159 (0.702-1.912)

0.564

Incomplete resection

1.886 (1.481-2.402)

<0.001

1.588 (1.152-2.189)

0.005

2.265 (1.533-3.347)

<0.001

Simultaneous CT

0.573 (0.427-0.767)

<0.001

0.592 (0.419-0.837)

0.003

0.535 (0.308-0.929)

0.026

Fractionation

1.061 (0.807-1.396)

0.672

-

-

-

-

Radiation treatment time

1.025 (0.985-1.068)

0.225

1.013 (0.960-1.070)

0.634

1.029 (0.964-1.098)

0.394

Age

1.034 (1.021-1.047)

<0.001

1.031 (1.015-1.047)

<0.001

1.040 (1.019-1.061)

<0.001

ECOG state > 1

1.006 (0.739-1.371)

0.968

1.027 (0.692-1.525)

0.893

0.947 (0.565-1.586)

0.835

RPA-class > 4

1.222 (0.914-1.634)

0.175

1.244 (0.692-1.790)

0.239

1.157 (0.700-1.913)

0.570

Incomplete resection

1.927 (1.510-2.460)

<0.001

1.642 (1.183-2.278)

0.003

2.301 (1.558-3.399)

<0.001

Simultaneous CT

0.584 (0.437-0.782)

<0.001

0.570 (0.405-1.801)

0.001

0.581 (0.335-1.009)

0.054

Fractionation

1.175 (0.865-1.595)

0.302

-

-

-

-

Overall duration of treatment

1.000 (0.989-1.010)

0.939

0.987 (0.971-1.002)

0.084

1.008 (0.995-1.021)

0.239

Age

1.033 (1.020-1.045)

<0.001

1.030 (1.014-1.046)

<0.001

1.040 (1.019-1.061)

<0.001

ECOG state > 1

1.005 (0.735-1.375)

0.974

0.858 (0.644-1.443)

0.858

0.976 (0.581-1.640)

0.928

RPA-class > 4

1.209 (0.905-1.616)

0.199

1.231 (0.855-1.773)

0.263

1.169 (0.708-1.931)

0.542

Incomplete resection

1.884 (1.479-2.399)

<0.001

1.571 (1.139-2.166)

0.006

2.256 (1.527-3.333)

<0.001

Simultaneous CT

0.568 (0.424-0.759)

<0.001

0.582 (0.413-0.821)

0.002

0.535 (0.308-0.928)

0.026

Fractionation

1.068 (0.805-1.418)

0.648

-

-

-

-

  1. The impact of time interval from surgery until initiation of radio- or radiochemotherapy (RCT), radiation treatment time and overall duration of local treatment from surgery to the end of radio- or radiochemotherapy on overall survival (OS) is shown