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Table 1 Dosimetric difference between SIB-IMRT and SEQ-IMRT strategies

From: A randomized phase II/III study of adverse events between sequential (SEQ) versus simultaneous integrated boost (SIB) intensity modulated radiation therapy (IMRT) in nasopharyngeal carcinoma; preliminary result on acute adverse events

Technique

BED (tumor)

BED (late)

SIB-IMRT (1-phase)

  

 PTV-HR = 2.12 x 33 = 70 Gy

84.8 Gy10

119.4 Gy3

 PTV-LR = 1.7 x 33 = 56 Gy

65.6 Gy10

87.9 Gy3

SEQ-IMRT (2-phase)

  

 PTV-HR = (2 x 25) + (2 x 10) = 70 Gy

84.00 Gy10

116.7 Gy3

 PTV-LR = 2 x 25 = 50 Gy

60.00 Gy10

83.3 Gy3

  1. Biological effective dose (BED) calculation is based on the linear-quadratic model for cell kill with an α / β ratio of 10 for tumors and an α / β ratio of 3 for late-responding normal tissue
  2. BED Total Dose (Gy) x (1 + dose per fraction(Gy))
  3. (α / β)
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Radiation Oncology

ISSN: 1748-717X

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