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Table 1 DNA damaging chemotherapeutic agents interacting with hyperthermia

From: Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all

Class Agent [with references to studies showing interaction of the agent with hyperthermia] Type of inflicted DNA damage Pathways involved in repair [references]
Alkylating agents - triazenes (temozolomide [182, 183]) strand cross-links, adducts, DSBs (indirect) NER, BER, MMR, NHEJ, HR [108, 184]
- nitrogen mustard derivatives (cyclophosphamide [13, 185191], melphalan [191199])
- aziridine-containing (mitomycin C [10, 187, 191, 200203])
Alkylating-like platinum compounds - cisplatin [12, 100, 101, 191, 201, 204210], carboplatin [211214], oxaliplatin [198, 199, 209, 215] strand cross-links, DSBs (indirect) NER, BER, MMR, HR [94, 95, 216, 217]
Antimetabolites - pyrimidine analogs (5-fluorouracil [218], gemcitabine [161, 199, 219]) SSBs, DSBs (indirect), oxidative damage HR, MMR, NER [148, 161, 220, 221]
- purine analogs (2-aminopurine [222], 6-thioguanine [222])
- dihydrofolate reductase inhibitors (methotrexate [210, 223])
Topoisomerase I poisons - camptothecin [224], B-lapachone [144, 145], Irinotecan [199] SSBs BER, NER, NHEJ [225, 226]
Topoisomerase II poisons - intercalators (doxorubicin [187, 188, 227230]) DSBs NHEJ, HR [231233]
Radiomimetics - enediynes (neocarzinostatin [10]) SSBs, DSBs, oxidative damage, strand cross-links HR, NHEJ, BER, [136, 137, 234, 235]
- bleomycin [6, 10, 12, 191, 210, 236, 237]
- mitomycin C [10, 187, 191, 200203]
PARP inhibitors - olaparib [150, 153], PJ-34 [150] SSBs, DSBs (indirect) HR, BER [238240]