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Fig. 2 | Radiation Oncology

Fig. 2

From: Mutant KRAS associated malic enzyme 1 expression is a predictive marker for radiation therapy response in non-small cell lung cancer

Fig. 2

Targeting glutamine metabolism sensitizes mutant KRAS NSCLC cell lines to radiation treatment. a, b Seven day clonogenic survival of HCC44 or H522 after radiation treatment after growth in either complete media or Gln deprived media for 16 h. c Clonogenic survival screen of mutant KRAS (H2009, H1573 and A549) or wild-type KRAS (H661, H322 and H596) NSCLC cell lines grown in either complete media or Gln deprived media for 16 h followed by treatment with 2 Gy of ionizing radiation. d Clonogenic survival of HCC44 and H522 pre-treated with 1 μM CB-839 for 48 h followed by treatment with various doses of ionizing radiation. All results were compared using Student’s t-tests as indicated. *p < 0.05; **p < 0.01; ***p < .001

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