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Table 2 The OARs multi-comparison analysis for all studied techniques (mean ± SD). Mean values with ǂ symbol demonstrate that the corresponding technique did not pass the normality test. Friedman test of significance (p < 0.05) was used in these cases; otherwise, repeated measures ANOVA significance test was used

From: Comparison of breast simultaneous integrated boost (SIB) radiotherapy techniques

N = 12   T-2 F T-NC T-VMAT f-VMAT
ILung V 20 (%) 14.1 ± 3.5ab 13.7 ± 3.5ab 14.8 ± 3.4ǂ a 13.3 ± 2.4ǂ b
  mean (Gy) 8.4 ± 1.6c 8.8 ± 1.5abc 9.1 ± 1.5ab 9.5 ± 0.9ǂ a
Heart (Lt.) V 30 (%) 1.3 ± 1.4a 1.0 ± 0.9ab 1.2 ± 1.4ǂ a 0* ǂ b
  mean (Gy) 3.0 ± 0.9b 2.8 ± 0.6b 3.5 ± 1.0ab 4.2 ± 0.4a
Heart (Rt.) V 30 (%) 0* a 0* a 0* a 0* a
  mean (Gy) 1.8 ± 0.3b 1.6 ± 0.3ǂ b 1.9 ± 0.4b 2.6 ± 0.2a
CBreast mean (Gy) 1.1 ± 0.3c 0.9 ± 0.2d 1.2 ± 0.3ab 1.8 ± 0.4ǂ a
CLung mean (Gy) 0.9 ± 0.2ǂ bc 0.7 ± 0.1c 1.1 ± 0.2ab 1.8 ± 0.3ǂ a
Uns. Tissue DSI 50.4 0.11 ± 0.05ǂ a 0.10 ± 0.05ǂ a 0.16 ± 0.07a 0.02 ± 0.01b
  DSI 5 1.42 ± 0.26b 1.31 ± 0.19b 1.38 ± 0.24b 2.65 ± 0.55a
  1. a,b,c,d Values having the same superscript in the same horizontal line are not significantly different
  2. *All the 12 patients have a 0 value
  3. V20 and V30 are volumes receiving 20 Gy and 30 Gy respectively; DSI50.4 and DSI5 are the prescribed (50.4 Gy) and low dose (5 Gy) spillage indexes outside the breast target volume