Increased SHP-1 expression results in radioresistance, inhibition of cellular senescence, and cell cycle redistribution in nasopharyngeal carcinoma cells

Table 1 Effects of SHP-1 knockdown and overexpression in CNE-1 and CNE-2 cells on radiosensitivity parameters

Radiosensitivity parameters	CNE-1	CNE-1-empty vector	CNE-1- scramble shRNA	CNE-1- SHP-1-overexpression	CNE-1- SHP-1- shRNA	CNE-2	CNE-2- empty vector	CNE-2- scramble shRNA	CNE-2- SHP-1- overexpression	CNE-2- SHP-1- shRNA
SF2	0.75	0.78	0.78	0.82	0.56	0.62	0.60	0.61	0.74	0.55
D₀	2.51	2.38	2.38	2.85	2.17	1.94	1.80	1.94	2.08	1.50
D_q	1.77	1.85	1.85	1.96	1.26	1.46	1.43	1.43	1.75	1.36
N	2.34	2.68	2.65	2.48	1.62	2.22	2.32	2.17	2.77	2.58

Note : SF2: cell survival fraction with 2 cGy irradiation dose; D0: mean lethal dose value; Dq: quasithreshold dose; N: extrapolation number

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