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Fig. 3 | Radiation Oncology

Fig. 3

From: Increased SHP-1 expression results in radioresistance, inhibition of cellular senescence, and cell cycle redistribution in nasopharyngeal carcinoma cells

Fig. 3

Effects of SHP-1 knockdown in CNE-1 cells and overexpression in CNE-2 cells on cell senescence. a Cell senescence was determined by β-galactosidase staining (magnification: ×400). Arrows: senescent cells. Heterochromatin markers H3K9Me3 and HP1γ location and protein expression were determined by immunofluorescence staining (b) (magnification: ×400; red: Alexa Fluor® 568) and western blot (c), respectively. β-actin was used as an inner control. Data are shown as mean ± SD. ** P < 0.01, *** P < 0.001 vs. CNE-1 or CNE-2; ## P < 0.01, ### P < 0.001 vs. CNE-1- scramble shRNA or CNE-2-empty vector

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