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Fig. 2 | Radiation Oncology

Fig. 2

From: Increased SHP-1 expression results in radioresistance, inhibition of cellular senescence, and cell cycle redistribution in nasopharyngeal carcinoma cells

Fig. 2

Effects of SHP-1 knockdown and overexpression on radiosensitivity in CNE-1 and CNE-2 cells. After stable transduction with lentivirus-mediated RNA interference and overexpression, CNE-1 (a) and CNE-2 (b) cells were irradiated at different doses (0, 2, 4, 6 and 8 Gy) (radiation absorption rate was 2 Gy/min). After further incubation for 14 days, colony formation assays were used to examine the radiosensitivity of the NPC cells. Survival curves were fitted according to the multi-target single-hit model. Compared with CNE-1 cells, cell survival was significantly different (all P < 0.05, ANOVA) for all radiation doses in CNE-1 cells with SHP-1 overexpression or silencing. Compared with CNE-2 cells, cell survival was significantly different (all P < 0.05, ANOVA) for all radiation doses in CNE-2 cells with SHP-1 overexpression or silencing. *P < 0.05, **P < 0.01, ***P < 0.001 empty vector vs. SHP-1-overexpression; ##P < 0.01, ###P < 0.001 scramble shRNA vs. SHP-1-shRNA

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Radiation Oncology

ISSN: 1748-717X

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