Table 3 Dosimetric comparison and statistical analysis of dose to normal brain and substructures

WV

Brain - D_mean

22.1 (21.2–23.3)

19.8 (18.4–21.3)

17.5 (15.9–18.7)

<0.05

<0.05

<0.05

Brain - V10Gy (%)

88.5 (85.5–90.0)

77.9 (74.8–82.1)

62.7 (55.6–66.5)

<0.05

<0.05

<0.05

Brain - V15Gy (%)

79.5 (75.9–83.6)

60.1 (54.0–64.8)

53.5 (45.5–57.0)

<0.05

<0.05

<0.05

Rt. Temporal

22.5 (18.6–25.8)

22.5 (18.6–25.8)

19.6 (14.8–23.7)

<0.05

<0.05

<0.05

Lt. Temporal

22.4 (18.9–27.2)

22.4 (18.9–27.2)

19.4 (15.4–25.6)

<0.05

<0.05

<0.05

Rt. Hippocampus

31.3 (30.4–31.6)

31.3 (30.4–31.6)

31.1 (27.4–31.2)

<0.05

NS

<0.05

Lt. Hippocampus

31.4 (31.2–31.5)

31.4 (31.2–31.5)

31.1 (28.7–31.2)

NS

<0.05

<0.05

Pituitary Gland

31.8 (30.9–31.9)

31.8 (30.9–31.9)

31.0 (30.7–31.4)

NS

NS

NS

PG

Brain - D_mean

10.5 (6.5–14)

8.3 (4.4–12.2)

7.0 (3.3–10.4)

<0.05

<0.05

<0.05

Brain - V10Gy (%)

47.8 (24.1–63.9)

25.4 (13.9–42.3)

21.1 (10.2–35.8)

<0.05

<0.05

NS

Brain - V15Gy (%)

26.1 (10.9–41.0)

20.5 (10.5–34.7)

16.4 (7.5–27.8)

<0.05

<0.05

<0.05

Rt. Temporal

15.0 (4.8–21.2)

2.8 (0.0–10.8)

2.0 (0.0–8.8)

<0.05

<0.05

NS

Lt. Temporal

14.7 (4.8–20.5)

2.9 (0.1–8.5)

3.0 (0.0–7.4)

<0.05

<0.05

NS

Rt. Hippocampus

28.0 (10.9–31.2)

25.1 (6.4–31.5)

21.8 (4.8–30.9)

NS

<0.05

NS

Lt. Hippocampus

25.8 (15.3–30.9)

23.0 (11.0–31.5)

22.3 (8.4–30.6)

NS

<0.05

<0.05

Pituitary Gland

6.8 (0.7–23.5)

5.0 (0.0–29.3)

3.2 (0.0–27.7)

NS

NS

NS

SS

Brain - D_mean

5.8 (4.9–11)

4.4 (3.6–7.9)

3.5 (2.9–6.7)

<0.05

<0.05

<0.05

Brain - V10Gy (%)

23.0 (18.3–49.0)

12.7 (10.2–27.1)

9.4 (7.6–22.6)

<0.05

<0.05

<0.05

Brain - V15Gy (%)

11.9 (9.8–25.9)

9.4 (7.6–21.8)

7.1 (5.6–17.2)

<0.05

<0.05

<0.05

Rt. Temporal

12.9 (8.8–15.8)

6.6 (4.3–9.9)

5.1 (3.4–6.9)

<0.05

<0.05

<0.05

Lt. Temporal

11.9 (9.1–15.4)

6.4 (3.0–9.5)

5.0 (2.4–6.7)

<0.05

<0.05

<0.05

Rt. Hippocampus

15.9 (11.7–17.5)

10.1 (4.6–16.1)

7.2 (2.4–12.6)

<0.05

<0.05

<0.05

Lt. Hippocampus

16.2 (12.7–17.5)

11.0 (6.2–15.3)

7.8 (3.7–13.5)

<0.05

<0.05

<0.05

Pituitary Gland

31.4 (5.9–31.6)

31.2 (15–31.4)

31.4 (14.4–32.2)

NS

NS

NS

BG

Brain - D_mean

12.4 (11.6–14.2)

8.8 (7.5–9.9)

7.7 (6.3–8.4)

<0.05

<0.05

<0.05

Brain - V10Gy (%)

56.5 (52.9–66.5)

29.1 (26.5–34.1)

25.2 (22.5–28.9)

<0.05

<0.05

<0.05

Brain - V15Gy (%)

33.6 (28.8–39.9)

24.3 (21.7–28.0)

20.1 (17.7–23.2)

<0.05

<0.05

<0.05

Ipsilat. Temp.

19.0 (13.2–22.6)

17.0 (13.8–23.1)

15.1 (10.4–20.3)

NS

<0.05

<0.05

Contralat. Temp.

10.3 (6.5–12.1)

0.0 (0.0–0.4)

0.0 (0.0–0.2)

<0.05

<0.05

NS

Ipsilat. Hippoc.

29.1 (24.3–31)

30.4 (27.1–31.2)

29.7 (24.6–31.1)

NS

NS

NS

Contralat. Hippoc.

15.6 (9.2–16.7)

0.2 (0.0–0.7)

0.1 (0.0–0.6)

<0.05

<0.05

NS

Pituitary Gland

12.5 (1.4–29.9)

22.4 (0.0–30)

11.5 (0.0–29.3)

NS

NS

NS