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Table 2 Dosimetric comparison and statistical analysis of PTV coverage

From: Differential dosimetric benefit of proton beam therapy over intensity modulated radiotherapy for a variety of targets in patients with intracranial germ cell tumors

Item PTV location Median (range, min–max) p value*
IMRT PSPT SSPT IMRT vs PSPT IMRT vs SSPT PSPT vs SSPT
PTV CI WV 0.85 (0.72–0.88) 0.70 (0.69–0.71) 0.91 (0.89–0.92) <0.05 <0.05 <0.05
PG 0.92 (0.87–0.92) 0.83 (0.62–0.87) 0.94 (0.90–0.90) <0.05 <0.05 <0.05
SS 0.89 (0.88–0.92) 0.74 (0.72–0.83) 0.92 (0.90–0.94) <0.05 <0.05 <0.05
BG 0.88 (0.86–0.91) 0.80 (0.74–0.82) 0.94 (0.93–0.95) <0.05 <0.05 <0.05
PTV GI WV 3.30 (3.08–3.75) 1.90 (1.85–2.04) 2.12 (1.99–2.19) <0.05 <0.05 <0.05
PG 3.89 (3.47–4.62) 2.90 (2.50–3.25) 2.50 (2.36–3.34) <0.05 <0.05 NS
SS 3.82 (3.71–4.14) 2.78 (2.64–3.27) 2.59 (2.48–2.87) <0.05 <0.05 NS
BG 3.77 (3.46–4.23) 2.35 (2.18–2.57) 2.30 (2.23–2.60) <0.05 <0.05 NS
PTV HI WV 0.97 (0.96–0.98) 0.95 (0.94–0.95) 0.98 (0.98–0.98) <0.05 <0.05 <0.05
PG 0.96 (0.95–0.97) 0.97 (0.96–0.98) 0.98 (0.97–0.98) NS <0.05 NS
SS 0.96 (0.95–0.97) 0.97 (0.96–0.98) 0.97 (0.95–0.98) NS NS NS
BG 0.97 (0.97–0.98) 0.97 (0.97–0.98) 0.97 (0.97–0.98) NS NS <0.05
PTV PQI WV 4.06 (3.82–4.73) 2.89 (2.75–3.11) 2.37 (2.23–2.46) 0.043 0.043 0.043
PG 4.39 (3.92–5.55) 3.38 (3.12–5.47) 2.70 (2.54–3.83) 0.043 0.043 0.043
SS 4.46 (4.26–4.88) 3.92 (3.62–4.05) 2.95 (2.88–3.12) 0.043 0.043 0.043
BG 4.45 (4.00–4.93) 3.01 (2.81–3.59) 2.49 (2.44–2.86) 0.043 0.043 0.043
  1. WV whole ventricle, PG pineal gland, SS suprasellar, BG basal ganglia, PTV planning target volume, CI conformity index, GI gradient index, HI homogeneity index, PQI plan quality index, IMRT intensity-modulated radiation therapy, PSPT passively scattered proton therapy, SSPT spot scanning proton therapy, NS not significant
  2. * p -value by Wilcoxon signed rank test