BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro

Table 2 Univariate and Multivariate analysis of factors associated with overall survival

Variables		Univariate analysis		Multivariate analysis
Variables	HR	95 %CI	P^a	HR	95%CI	P^a
Gender	0.725	0.320-1.642	0.440
Male vs Female	0.725	0.320-1.642	0.440
Age (years)	1.106	0.589-2.077	0.753
<45 vs ≥ 45	1.106	0.589-2.077	0.753
Histological classification	1.602	0.568-4.516	0.373
Type II vs Type III	1.602	0.568-4.516	0.373
Clinical stage	3.402	1.651-7.007	0.001
I-II vs III-IV	3.402	1.651-7.007	0.001
T classification	1.886	0.999-3.558	0.050
T1-T2 vs T3-T4	1.886	0.999-3.558	0.050
N classification	2.328	1.233-4.395	0.009
N0 vs N1-N3	2.328	1.233-4.395	0.009
Distant metastasis	6.223	3.091-12.529	<0.001	7.026	2.898-17.037	<0.001
No vs Yes	6.223	3.091-12.529	<0.001	7.026	2.898-17.037	<0.001
Relapse	2.648	1.248-5.619	0.011	5.081	2.017-12.802	0.001
No vs Yes	2.648	1.248-5.619	0.011	5.081	2.017-12.802	0.001
Skull-based invasion	2.483	1.226-5.029	0.012	2.996	1.258-7.133	0.013
No vs Yes	2.483	1.226-5.029	0.012	2.996	1.258-7.133	0.013
Radiotherapy response	2.949	1.462-5.946	0.003
Sensitive vs Resistant	2.949	1.462-5.946	0.003
BRCC3	3.560	1.821-6.958	<0.001	2.674	1.270-5.630	0.010
Low vs High	3.560	1.821-6.958	<0.001	2.674	1.270-5.630	0.010

Abbreviation: OS, overall survival; 95 % CI, 95 % confidence interval; HR, hazard ratio
^a. Cox proportional hazards model

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