Table 2 Summary of randomized trials of dose-escalated external beam radiotherapy
Study | MDACC (1) | Dutch (2, 3,4) | PROG (5, 6) | MRC RT01 (7, 8) | GETUG 06 (9) |
|---|---|---|---|---|---|
Dose (technique) | 78 Gy (4-fld box + 3D-CRT) vs 70 Gy (4-fld box) | 78 Gy (4-fld box + 3D-CRT/IMRT) vs 68 Gy (4-fld box) | 79.2 GyE (4-fld box + proton boost) vs 70.2 Gy (4-fld box + proton boost) | 74 Gy (3D-CRT) vs 64 Gy (3D-CRT) | 80 Gy (3D-CRT) vs 70 Gy (3D-CRT) |
Median F/U (yrs) | 9 | 5.8 | 8.9 | 5.2 | 5.1 |
*PTV margins (mm) | Ant/Inf 12.5 -15 Post/Sup 7.5 -10 | 10 to 68 Gy 5 for 10 Gy boost 0 Post | 10 to 50.4 Gy 5 for 28.8 GyE (proton boost) | 5 - 10 | Ant/Sup/Inf/RL 10 Post 5 |
*Late toxicity (%) | RTOG | RTOG | RTOG | RTOG | RTOG |
≥ Grade 2 | |||||
GI | 26 | 35 | 24 | 33 | 20 |
GU | 13 | 40 | 29 | 11 | 18 |
Grade 3 | |||||
GI | 7 | 5 | 1 | 4 | 6 |
GU | 4 | 7 | 2 | 0 | 2 |
Grade 4 | |||||
GI | none | 1 patient | none | none | none |
GU | none | none | none | none | 1 patient |
Biochemical control (%) | Phoenix | ASTRO | ASTRO | ASTRO | Phoenix |
5Â yr - 85 vs 78 | 7Â yr - 54 vs 47 | 5Â yr - 80 vs 61 | 5Â yr - 71 vs 59 | 5Â yr - 76 vs 68 | |
8Â yr - 78 vs 59 | Phoenix | 10Â yr - 83 vs 68 | Â | Â | |
10Â yr - 73 vs 50 | 7Â yr - 54 vs 45 | Â | Â | Â | |