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Table 3 Grade 2+ toxicities in ACC patients treated with chemoradiation by treatment cohort

From: Intensity-Modulated Radiotherapy (IMRT) vs Helical Tomotherapy (HT) in Concurrent Chemoradiotherapy (CRT) for Patients with Anal Canal Carcinoma (ACC): an analysis of dose distribution and toxicities

Toxicity

Total

IMRT

HT

P-value*

 

(N = 35)

(N = 18)

(N = 17)

 
 

n (%)

n (%)

n (%)

 

Grade 2+ Hematologic Toxicities

    

Leukopenia

27 (77.1)

13 (72.2)

14 (82.4)

0.69

Neutropenia

22 (62.9)

10 (55.6)

12 (70.6)

0.36

Thrombocytopenia

13 (37.1)

6 (33.3)

7 (41.2)

0.63

Anemia

11 (31.4)

5 (27.8)

6 (35.3)

0.63

Febrile neutropenia requiring hospitalization

5 (14.3)

1 (5.6)

4 (23.5)

0.18

Grade 2+ Non-Hematologic Toxicities

    

Skin

29 (82.9)

14 (77.8)

15 (88.2)

0.66

Upper GI

9 (25.7)

6 (33.3)

3 (17.7)

0.44

Lower GI

18 (51.4)

12 (66.7)

6 (35.3)

0.06

GU

3 (8.6)

2 (11.1)

1 (5.9)

1.00

Unscheduled treatment break

8 (22.9)

6 (33.3)

2 (11.8)

0.23

  1. *Fisher exact testing used where any cell n < 5, otherwise Chi-square testing used.
  2. RTOG acute radiation morbidity scoring criteria [17].