Table 2 Univariate and multivariate analysis of variables affecting overall survival
Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age | ||||||
<65 | 1 | 1 | ||||
≥65 | 2.14 (1.60-2.86) | <.0001 | 1.25 (0.86-1.82) | 0.235 | ||
KPS | ||||||
<70 | 1 | 1 | ||||
≥70 | 0.51 (0.35-0.74) | 0.0004 | 0.67 (0.43-1.05) | 0.078 | ||
Extent of surgery | ||||||
Biopsy | 1 | 1 | ||||
STR | 0.54 (0.38-0.79) | 0.0013 | 0.62 (0.39-0.99) | 0.048 | ||
GTR | 0.36 (0.23-0.56) | <.0001 | 0.39 (0.22-0.67) | 0.001 | ||
Treatment | ||||||
60 Gy/30 fr | 1 | 1 | ||||
60 Gy/20 fr | 1.15 (0.86-1.56) | 0.3475 | 1.27 (0.93-1.74) | 0.126 | ||
40 Gy/15 fr | 4.07 (2.75-6.04) | <.0001 | 2.22 (1.30-3.80) | 0.004 | ||
Chemotherapy | ||||||
No | 1 | 1 | ||||
Yes | 0.20 (0.12-0.34) | <.0001 | 0.52 (0.28-0.99) | 0.045 | ||
Repeat surgery | ||||||
No | 1 | 1 | ||||
Yes | 0.51 (0.38-0.70) | <.0001 | 0.62 (0.44-0.86) | 0.005 | ||
MGMT | ||||||
Unmethylated | 1 | 1 | ||||
Methylated | 0.53 (0.39-0.74) | 0.0001 | 0.46 (0.33-0.64) | <.0001 | ||